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Pir or PIR may refer to:
Religion and history
- Pir (Sufism), a Sufi teacher, spiritual leader
- Pir (Zoroastrianism), a site in Persia, frequently one of the Zoroastrian faith
- Pir of the Britons, legendary king of the Britons
- Protein Information Resource, a major protein information database and bioinformatics resource
- Partners in Research, a Canadian charity dedicated to bio-medical research
- Passive infrared sensor or PIR sensor, an electronic device that measures infrared emission; often used for motion detection
- PIR (gene), the gene for a human protein that is a possible transcriptional coregulator
- Polyisocyanurate, a plastic typically produced as a foam for thermal insulation
- Peak information rate
- Public Interest Registry, a not-for-profit corporation responsible for managing the .org top-level domain.
- Private information retrieval, a protocol that allows a user to retrieve an item from a server in possession of a database without revealing which item she is retrieving
- Parrot intermediate representation, one of the two assembly languages for the Parrot virtual machine
- Pierre Regional Airport, South Dakota, U.S.
- Pir, East Azerbaijan, a village in East Azerbaijan Province, Iran
- Pir, Kerman, a village in Kerman Province, Iran
- Pir, Satu Mare, commune in Satu Mare County, Romania
- Parachute infantry regiment, a unit of airborne forces
- Ministry of Public Infrastructure Renewal (Ontario), a former ministry of the Government of Ontario
- The Price Is Right (US game show), a TV gameshow
- Pittsburgh Industrial Railroad
- Performance Index Rating, a statistical formula used in basketball
- Pier 1 Imports, NYSE symbol PIR, a Texas-based retailer specializing in imported home furnishings and decor
- Personnel and industrial relations, a subfield of human resources
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