Piroxicam

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Piroxicam

Systematic (IUPAC) name
(8E)-8-[hydroxy-(pyridin-2-ylamino)methylidene]- 9-methyl-10,10-dioxo-10λ6-thia-9-azabicyclo[4.4.0] deca-1,3,5-trien-7-one
Identifiers
CAS number	36322-90-4
ATC code	M01AC01 M02AA07, S01BC06
PubChem	5280452
DrugBank	APRD01187
ChemSpider	10442653
Chemical data
Formula	C15H13N3O4S
Mol. mass	331.348 g/mol
Pharmacokinetic data
Bioavailability	?
Metabolism	4 to 10% renal
Half life	30 to 86 hours
Excretion	4 to 10% renal
Therapeutic considerations
Pregnancy cat.	C, D if used in the third trimester or near delivery
Legal status	POM
Routes	PO
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Piroxicam is a non-steroidal anti-inflammatory drug used to relieve the symptoms of rheumatoid and osteoarthritis, primary dysmenorrhoea, postoperative pain; and act as an analgesic, especially where there is an inflammatory component. It is manufactured by Pfizer under the tradename Feldene, and is available in the  United Kingdom,  Australia,  Italy and  United States. It is also manufactured by Bosnalijek under the tradename Roxam, and is available in Eastern Europe, Africa, and the Middle East.

It is also used in veterinary medicine to treat certain neoplasias expressing cyclooxygenase (COX) receptors, such as bladder, colon, and prostate cancers.

Other brand names for Piroxicam include "Brexidol", "Brexin", "Erazon", "Exipan", "Felden", "Feldoral", "Hotemin", "Pirox von ct", "Proponol", "Reumador", "Tracam", "Veral", "Mobilis" and "Vurdon", "Roxam".

[edit] Mechanism of action

Piroxicam is an NSAID and, as such, is a non-selective COX inhibitor possessing both analgesic and antipyretic properties. It undergoes enterohepatic circulation.

[edit] Adverse effects

Piroxicam use can result in gastrointestinal toxicity, tinnitus, dizziness, headache, rash, and pruritus. The most severe adverse reactions are peptic ulceration and gastrointestinal bleeding. Approximately 30% of all patients receiving daily doses of 20 mg of piroxicam experience side effects.^[1]

Piroxicam may cause skin to become more sensitive to sunlight.^[2] Avoidance of sunlight and use of sunscreen is recommended.^{[citation needed]}

[edit] Footnotes