Pitrazepin

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Pitrazepin
Pitrazepin-ifa.png
Systematic (IUPAC) name
3-(piperazin-1-yl)-9H-dibenzo[c,f][1,2,4]triazolo[4,3-a]azepine
Clinical data
Pregnancy cat.
  •  ?
Legal status
  • Uncontrolled
Routes ?
Identifiers
CAS number 90685-01-1
ATC code None
PubChem CID 146222
ChemSpider 128982
Chemical data
Formula C19H19N5 
Mol. mass 317.39 g/mol

Pitrazepin is a competitive GABAA and glycine receptor antagonist.[1][2][3] It has been used to study insect and snail nervous systems in scientific research.[4][5][6][7][8][9]

See also[edit]

References[edit]

  1. ^ Gähwiler BH, Maurer R, Wüthrich HJ (April 1984). "Pitrazepin, a novel GABAA antagonist". Neuroscience Letters 45 (3): 311–6. doi:10.1016/0304-3940(84)90244-1. PMID 6328380. 
  2. ^ Braestrup C, Nielsen M (November 1985). "Interaction of pitrazepin with the GABA/benzodiazepine receptor complex and with glycine receptors". European Journal of Pharmacology 118 (1-2): 115–21. doi:10.1016/0014-2999(85)90669-7. PMID 3002806. 
  3. ^ Curtis DR, Gynther BD (November 1986). "Pitrazepin: a central glycine and GABA antagonist". European Journal of Pharmacology 131 (2-3): 311–3. doi:10.1016/0014-2999(86)90590-X. PMID 3816960. 
  4. ^ Anthony NM, Harrison JB, Sattelle DB (1993). "GABA receptor molecules of insects". Exs 63: 172–209. doi:10.1007/978-3-0348-7265-2_8. PMID 7678525. 
  5. ^ Sattelle DB, Pinnock RD, Wafford KA, David JA (January 1988). "GABA receptors on the cell-body membrane of an identified insect motor neuron". Proceedings of the Royal Society B 232 (1269): 443–56. doi:10.1098/rspb.1988.0006. PMID 2451252. 
  6. ^ Murphy VF, Wann KT (November 1988). "The action of GABA receptor agonists and antagonists on muscle membrane conductance in Schistocerca gregaria". British Journal of Pharmacology 95 (3): 713–22. doi:10.1111/j.1476-5381.1988.tb11697.x. PMC 1854212. PMID 2850061. 
  7. ^ Zhang W, Han XY, Wong SM, Takeuchi H (January 1997). "Pharmacologic characteristics of excitatory gamma-amino-butyric acid (GABA) receptors in a snail neuron". General Pharmacology 28 (1): 45–53. doi:10.1016/S0306-3623(96)00152-8. PMID 9112076. 
  8. ^ Kim KH, Takeuchi H (June 1990). "Pharmacological characteristics of two different types of inhibitory GABA receptors on Achatina fulica neurones". European Journal of Pharmacology 182 (1): 49–62. doi:10.1016/0014-2999(90)90492-O. PMID 2169426. 
  9. ^ Takeuchi H (September 1992). "Sensitivities of Achatina giant neurones to putative amino acid neurotransmitters". Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology 103 (1): 1–12. doi:10.1016/0742-8413(92)90219-w. PMID 1360362.