Plasminogen activator

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A plasminogen activator is a serine protease which converts plasminogen to plasmin, thus promoting fibrinolysis.

Types include:

It is inhibited by plasminogen activator inhibitor-1 and plasminogen activator inhibitor-2.

v t e Endopeptidases: serine proteases/serine endopeptidases (EC 3.4.21)

Digestive enzymes	Enteropeptidase · Trypsin · Chymotrypsin · Elastase (Neutrophil, Pancreatic)

Coagulation	factors: Thrombin · Factor VIIa · Factor IXa · Factor Xa · Factor XIa · Factor XIIa · Kallikrein (PSA, KLK1, KLK2, KLK3, KLK4, KLK5, KLK6, KLK7, KLK8, KLK9, KLK10, KLK11, KLK12, KLK13, KLK14, KLK15) fibrinolysis: Plasmin · Plasminogen activator (Tissue plasminogen activator · Urinary plasminogen activator)

Complement system	Factor B · Factor D · Factor I · MASP (MASP1, MASP2) · C3-convertase

Other immune system	Chymase · Granzyme · Tryptase · Proteinase 3/Myeloblastin

Venombin	Ancrod · Batroxobin

Other	Acrosin · Prolyl endopeptidase · Pronase · Proprotein convertases (1, 2) · Reelin · Subtilisin/Furin · Streptokinase · S1P · Cathepsin (A, G)

B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6

Antithrombotics (thrombolytics)

Antiplatelet drugs

Glycoprotein IIb/IIIa inhibitors	Abciximab Eptifibatide Tirofiban

ADP receptor/P2Y₁₂ inhibitors	thienopyridines (Clopidogrel Prasugrel Ticlopidine) nucleotide/nucleoside analogs (Cangrelor Elinogrel Ticagrelor)

Prostaglandin analogue (PGI2)	Beraprost Prostacyclin Iloprost Treprostinil

COX inhibitors	Acetylsalicylic acid/Aspirin^# Aloxiprin Carbasalate calcium Indobufen Triflusal

Thromboxane inhibitors	thromboxane synthase inhibitors (Dipyridamole Picotamide) receptor antagonist (Terutroban^†)

Phosphodiesterase inhibitors	Cilostazol Dipyridamole Triflusal

Other	Cloricromen Ditazole

Vitamin K antagonists
(inhibit II, VII, IX, X)

other: Tioclomarol

Factor Xa inhibitors
(with some II inhibition)

Heparin group/ glycosaminoglycans/ (bind antithrombin)	low-molecular-weight heparin (Bemiparin Certoparin Dalteparin Enoxaparin Nadroparin Parnaparin Reviparin Tinzaparin) oligosaccharides (Fondaparinux Idraparinux) heparinoid (Danaparoid Sulodexide Dermatan sulfate)

Direct Xa inhibitors	xabans (Apixaban Betrixaban Edoxaban Otamixaban Rivaroxaban)

Direct thrombin (II) inhibitors

Other

Thrombolytic drugs/
fibrinolytics

plasminogen activators: r-tPA (Alteplase
Reteplase
Tenecteplase)
UPA (Urokinase
Saruplase)
Streptokinase^#
Anistreplase
Monteplase

^#WHO-EM
^‡Withdrawn from market
Clinical trials:
- ^†Phase III
- ^§Never to phase III

cell/phys (coag, heme, immu, gran), csfs

rbmg/mogr/tumr/hist, sysi/epon, btst

drug (B1/2/3+5+6), btst, trns

This drug article relating to the blood and blood forming organs is a stub. You can help Wikipedia by expanding it.

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