Plasmodium chabaudi

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Plasmodium chabaudi
Scientific classification
Kingdom: Protista
Phylum: Apicomplexa
Class: Aconoidasida
Order: Haemosporida
Family: Plasmodiidae
Genus: Plasmodium
Species: P. chabaudi
Binomial name
Plasmodium chabaudi

Plasmodium chabaudi is a parasite of the genus Plasmodium subgenus Vinckeia.

Like all Plasmodium species P. chabaudi has both vertebrate and insect hosts. The vertebrate hosts for this parasite are rodents.[1]

Description[edit]

This species was described in 1965 by I. Landau.[2] It is named after Pr Alain Chabaud.

Genome[edit]

The nuclear genome is 18.8 megabases in size with a karyotype of 14 chromosomes. The G+C content is ~23%. A genome sequencing project is underway.

Geographical occurrence[edit]

This species is found in Africa. This species was first isolated from the blood of a shiny thicket rat (Thamnomys rutilans) in the Central African Republic.[3]

Clinical features and host pathology[edit]

While it is difficult to study P. chabaudi in its natural host given the difficulty of taming the thicket rat, it has been studied extensively in laboratory mice, largely using the clone P. chabaudi chabaudi (AS). The pathology resembles that of human malaria in that animals are susceptible to parasite growth and pathology such as anemia, hypoglycemia, changes in body temperature, weight loss, and occasional death. The other cloned strains vary in growth rates and virulence.[4] One unique feature of this species is its prolonged course of infection. While it seems to persist for years in the thicket rat, P. chabaudi (AS) lasts up to three months in BALB/c or C57Bl/6 mice [5] P. falciparum has been observed to persist for up to a year,[6] and even in conditions of drought when there are no new infections.[7] Other species that are used to model human infection do not have this property. The other unique properties of this parasite are that it is synchronous, as first described for malaria by Galen, and that it prefers to infect normocytes, similar to P. falciparum, the most virulent human parasite, while several of the other rodent parasites have a preference for immature red blood cells, or reticulocytes, which they share with P. vivax.

Notes[edit]

Two subspecies have been defined: P. chabaudi chabaudi and P. chabaudi adami.

External links[edit]

References[edit]

  1. ^ Hoffman, Stephen P. (1996). Malaria Vaccine Development: A Multi-Immune Response Approach. American Society Microbiology. ISBN 1-55581-111-6. 
  2. ^ Landau I. (1965) Description de Plasmodium chabaudi n. sp., parasite de rongeurs africains. C. R. Hebd. Séances Acad. Sci. 260:3758-3761.
  3. ^ Trans R Soc Trop Med Hyg. 1966;60(5):633-49. Rodent plasmodia of the République Centrafricaine: the sporogony and tissue stages of Plasmodium chabaudi and P. berghei yoelii. Landau I, Killick-Kendrick R.
  4. ^ The contribution of Plasmodium chabaudi to our understanding of malaria. Stephens R, Culleton RL, Lamb TJ. Trends Parasitol. 2012 Feb;28(2):73-82. http://www.sciencedirect.com/science/article/pii/S147149221100184X
  5. ^ Parasite Immunol. 2007 Sep;29(9):435-44. Malaria-specific antibody responses and parasite persistence after infection of mice with Plasmodium chabaudi chabaudi. Achtman AH1, Stephens R, Cadman ET, Harrison V, Langhorne J.
  6. ^ A retrospective examination of sporozoite-induced and trophozoite-induced infections with Plasmodium ovale: development of parasitologic and clinical immunity during primary infection. Collins WE, Jeffery GM. Am J Trop Med Hyg. 2002 May;66(5):492-502.
  7. ^ Characteristics of Plasmodium falciparum parasites that survive the lengthy dry season in eastern Sudan where malaria transmission is markedly seasonal. Babiker HA, Abdel-Muhsin AM, Ranford-Cartwright LC, Satti G, Walliker D. Am J Trop Med Hyg. 1998 Oct;59(4):582-90.