Platelet alpha-granule

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Alpha granule
Latin granulum alpha
Code TH H2.00.04.1.03005

In platelets, the term "alpha granules" is used to describe granules containing several growth factors.[1]

Contents[edit]

Contents include insulin-like growth factor 1, platelet-derived growth factor, TGFβ, platelet factor 4 (which is a heparin-binding chemokine) and other clotting proteins (such as thrombospondin, fibronectin, and von Willebrand factor).

The alpha granules express the adhesion molecule P-selectin[2] and CD63.[3] These are transferred to the membrane after synthesis.

The other type of granules within platelets are called dense granules.

Clinical significance[edit]

A deficiency of alpha granules is known as gray platelet syndrome.

See also[edit]

References[edit]

  1. ^ Harrison P, Cramer E (1993). "Platelet alpha-granules.". Blood Rev 7 (1): 52–62. doi:10.1016/0268-960X(93)90024-X. PMID 8467233. 
  2. ^ Stuart H. Orkin; David G. Nathan; David Ginsburg; A. Thomas Look (2009). Nathan and Oski's hematology of infancy and childhood. Elsevier Health Sciences. pp. 1386–. ISBN 978-1-4160-3430-8. Retrieved 2 November 2010. 
  3. ^ William B. Coleman; Gregory J. Tsongalis (2009). Molecular pathology: the molecular basis of human disease. Academic Press. pp. 258–. ISBN 978-0-12-374419-7. Retrieved 2 November 2010.