Polidocanol

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Polidocanol
Polidocanol skeletal.svg
Systematic (IUPAC) name
2-(dodecyloxy)ethan-1-ol
Clinical data
AHFS/Drugs.com International Drug Names
Pregnancy cat. Topical: allowed
Injection: contraindication in months 1–3 and after week 36
Legal status OTC (topical), (injection)
Identifiers
CAS number 9002-92-0 YesY
3055-99-0 (with nine ethyleneglycol units)
ATC code C05BB02
PubChem CID 656641
UNII 0AWH8BFG9A N
KEGG D01993 YesY
ChEMBL CHEMBL1201751 N
Synonyms

 

  • Polydocanol
  • Laureth 9
  • Macrogol lauryl ether
  • Lauromacrogol
  • PEG-9 lauryl alcohol
  • POE-9 lauryl alcohol
  • Dodecylpolyethyleneglycolether
  • Hydroxyl polyethoxy dodecane
  • Oxypolyethoxydodecane
Chemical data
Formula C30H62O10 
Mol. mass ~600 g/mol (average)
 N (what is this?)  (verify)

Polidocanol is a local anaesthetic and antipruritic component of ointments and bath additives. It relieves itching caused for example by dry skin conditions such as eczema.[1]

The substance is also used as a sclerosant, an irritant injected to treat varicose veins, under the trade names Asclera and Aethoxysklerol.[2] Polidocanol causes fibrosis inside varicose veins, occluding the lumen of the vessel, and reducing the appearance of the varicosity.

The FDA has approved polidocanol injections for the treatment of small varicose (less than 1 mm in diameter) and reticular veins (1 to 3 mm in diameter). Polidocanol works by damaging the cell lining of blood vessels, causing them to close and eventually be replaced by other types of tissue.[3][4]

Pure polidocanol for pharmaceutical use

References[edit]

  1. ^ "E45 itch relief cream". netdoctor.co.uk. Retrieved 2007-07-12. 
  2. ^ Sclerotherapy, Laurence Z Rosenberg, MD, eMedicine.com
  3. ^ Facts and Companies: Varicose Vein Treatment Approved
  4. ^ "Asclera Full Prescribing Information in Drug Reference Encyclopedia". Retrieved 2010-04-11.