The show originally aired on weekends but eventually was moved to an 8-9 PM nightly slot. In May 2007 the show was cancelled in favor of a show called The Air Americans, to which Bender was also a contributor. (That show was cancelled in August 2007.)
Politically Direct returned to Air America on June 8, 2008, as a replacement for the cancelled Seder on Sundays program. The show airs in Seder's former timeslot of 4 to 7 PM. Bender returned to host, leaving his position on accompanying weekend show Ring of Fire to do so.
Politically Direct started as a weekend show on Air America in 2005. In September 2006, it was moved to a nightly time slot . Host David Bender started at Air America in 2004 as the network's political director. During the 2004 elections, Bender and fellow Air America personality Rachel Maddow hosted a Sunday show that summarized the weekend political talk shows, with an emphasis on countering bias and "spin" pertaining to the race. After the election, the show was moved to a regular slot on weekends, and followed its current format of in-depth interviews.
The theme song of Politically Direct is "If I Were You" by the group Venice.