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Polygenesis can refer to:
- Polygenesis (biology), a theory of multiple independent origins of organisms from a common genetic pool. See work by Leonid Moroz, Christian Schwabe, or Periannan Senapathy.
- Polygenesis (genetics), a form of genetic disorder resulting in the overexpression of a particular gene
- Polygenesis (linguistics), a theory of language origin
- Polygenism, a theory of human origin
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