Popes Creek is an unincorporated community in Charles County, Maryland, United States. It is located on the shore of a north-south section of the Potomac River north of and in sight of the Harry Nice Memorial Bridge. There are docks and two very popular seafood restaurants. U.S. Route 301 in Maryland runs north from the bridge, somewhat isolating the area between the river and the highway. To the north is Port Tobacco Village, Maryland and to the southeast the Cobb Island peninsula.
It is home to the Loyola Roman Catholic retreat center. Near here, John Wilkes Booth was rowed across the river, a week after he assassinated President Abraham Lincoln. Popes Creek (Virginia) is on the Virginia shore about 15 miles (24 km) southeast.