Cervical cancer is a tumour of the cervix, the junction between the uterus and vagina in the female reproductive tract. Certain types of human papillomavirus (HPV) are implicated in more than 90% of these cancers, although the great majority of HPV infections of the cervix are not associated with cancer. HPV is transmitted by vaginal sex, infecting cervical epithelial cells. In 5–10% of cases, infection persists for years, and pre-cancerous changes called cervical intraepithelial neoplasia can develop. These can regress, but sometimes progress to cancer. Although in nearly all forms of the cancer, HPV infection is considered essential for cancer to develop, other risk factors are involved, including smoking, HIV infection and other forms of immune suppression.
Cervical cancer is the fourth most common cancer in women worldwide. It can be detected by screening; screening every 3–5 years, with appropriate follow-up, can reduce cancer incidence by up to 80%. HPV vaccines protect against types 16 and 18, which cause three-quarters of cancers. Where screening and vaccination are not available, cervical cancer has substantial mortality; worldwide, an estimated 528,000 cases and 266,000 deaths occurred in 2012, with 80% of these being in developing countries.
Reverse transcriptase is an enzyme that makes complementary DNA from an RNA template. It was discovered in 1970 by Howard Temin in Rous sarcoma virus, a retrovirus that causes tumours in chickens, and independently the same year by David Baltimore, for which the two shared the Nobel Prize in Physiology or Medicine. The discovery was initially controversial, as reverse transcription contradicts the central dogma of molecular biology, that information flows from DNA to RNA to protein.
Reverse transcription is essential for the replication of retroviruses, and allows them to integrate into the host genome as a provirus. The enzyme is a target for reverse-transcriptase inhibitors, an important class of anti-HIV drugs. The process is also important in eukaryotic genomes, in the replication of chromosome ends and retrotransposons, a type of mobile genetic element. Reverse transcriptase is widely used in the laboratory for molecular cloning, RNA sequencing, polymerase chain reaction and genome analysis.
24 March: A small study of a multivalent norovirus virus-like particle vaccine shows a broad antibody response is generated, which covers novel virus variants. PLOS Med
24 March: An Ebola vaccine (virus pictured) based on the 2014 strain is shown to be safe and to generate an immune response in a phase I clinical trial in China. Lancet
23 March: A novel virus, ANMV-1, believed to infect anaerobic archaea in a deep-sea methane seep, is shown to have the first diversity-generating retroelement found in archaea or their viruses, which has the potential to generate rapid genetic diversity in the virus. Nat Comm
22 March: The lowest weekly total of new cases of Ebola virus disease in 2015 has been recorded in the ongoing West African outbreak; since the outbreak began, there have been nearly 25,000 suspected cases and 10,326 deaths. WHO
18 March: A test to distinguish viral from bacterial infections is developed, based on TRAIL (pictured) and other host proteins induced after infection. PLOS ONE
10 March: In the ongoing outbreak of Middle East respiratory syndrome coronavirus (MERS-CoV; pictured), cases continue to be reported in Saudi Arabia; since the outbreak started in September 2012, there have been 1075 cases with at least 404 deaths. WHO
9 March: Real-time imaging of SIV in macaques using immuno-PET reveals unexpectedly high levels of virus in the nasal cavity, lung and male genital tract in antiretroviral-treated animals. Nat Meth
4 March: The International Committee on Taxonomy of Viruses formally ratify their 2014 species list, with one new family of double-stranded DNA bacteriophages, Sphaerolipoviridae, one new subfamily of Myoviridae, Eucampyvirinae, fifty new genera and 359 new species recognised. ICTV
3 March: Four RNA viruses found in farmed honeybees – acute bee paralysis, black queen cell, deformed wing and slow bee paralysis viruses – are widespread among wild bumblebee species in a survey across Britain. J Anim Ecol
2 March: A 3D image of Acanthamoeba polyphaga mimivirus at 125 nm resolution is constructed from multiple high-energy X-ray diffraction patterns of single virions, rather than crystals, in the first application of this technique to a virus. Nature
25 February: H7N9 avian influenza infection continues in China, with 59 cases reported since 21 January. WHO
25 February: WHO calls for increased measles vaccination coverage in the light of outbreaks across Europe; the ongoing outbreak in North America continues. WHO,CDC
24 February: A clinical trial in England shows that pre-exposure prophylaxis with tenofovir/emtricitabine (Truvada) reduces the risk of HIV infection by 86% in gay men engaging in high-risk sex. CROI
18 February: Varicella zoster virus antigens are found in 74% of giant cell arteritis biopsies but only 8% of normal ones, suggesting the virus might have a role in triggering disease. Neurology
29 January: A total of 112 novel negative-sense RNA viruses of arthropods, including a putative new family of circular RNA viruses, are identified in a study of 70 arthropod species in China. e-Life