Portugal–Uruguay relations are foreign relations between Portugal and Uruguay. Portugal has an embassy in Montevideo. Uruguay has an embassy in Lisbon.
Ever since colonial times, Portugal has had interests in the Río de la Plata region; its relationship with the Banda Oriental began in 1680, when Colonia del Sacramento was established. For some years, the present territory of Uruguay was part of the Portuguese Empire under the denomination of Cisplatine Province.
Both countries are full members of the United Nations, of the Latin Union and of the Organization of Ibero-American States.
Portugal is becoming a significant trading partner for Uruguay. There is a Uruguayan-Portuguese Chamber of Commerce.
In 2009, both countries undersigned a bilateral agreement to avoid double taxation.