Post-translational regulation

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Post-translational regulation refers to the control of the levels of active protein.

There are several forms.^[1]

It is performed either by means of reversible events (Post-translational modifications, such as Phosphorylation or sequestration) or by means of irreversible events (proteolysis).

[edit] References

v t e Gene expression

Introduction to genetics	General flow: DNA > RNA > Protein special transfers (RNA > RNA, RNA > DNA, Protein > Protein) Genetic code

Transcription	(Transcription factors, RNA Polymerase,promoter) Prokaryotic / Archaeal / Eukaryotic post-transcriptional modification (hnRNA,5' capping,Splicing,Polyadenylation)

Translation	(Ribosome,tRNA) Prokaryotic / Archaeal / Eukaryotic post-translational modification (functional groups, peptides, structural changes)

Gene regulation	epigenetic regulation (Genomic imprinting) transcriptional regulation post-transcriptional regulation (sequestration, alternative splicing, miRNA) translational regulation post-translational regulation (reversible, irreversible)

Overview

Dogma	History of molecular biology • DNA Replication (DNA), Transcription (RNA) - Translation (protein)

Element	(Genetic • Heredity) Promoter (Pribnow box, TATA box) • Operon (gal operon, lac operon, trp operon) • Intron • Exon • Terminator • Enhancer • Repressor (lac repressor, trp repressor) • Silencer • Histone methylation

Linked Life	Cell Biology • Biochemistry • Computational Biology • Genetics

Engineering

Concept	mitosis • cell signalling • Post-transcriptional modification and Post-translational modification • Dry Lab/Wet lab

Technique	Cell culture • model organisms (such as C57BL/6 mice) • method (Nucleic acid • Protein) • Fluorescence, Pigment & Radioactivity High-throughput Technique (-omics): DNA microarray • Mass spectrometry • Lab-on-a-chip

Gene regulation	Epigenetic • genetic • post-transcriptional • post-translational regulation