Posterior column–medial lemniscus pathway
|Posterior column-medial lemniscus pathway|
The formation of the spinal nerve from the dorsal and ventral roots.
|Latin||via columnae posterioris lemniscique medialis|
|Precursor||Neural tube and crest|
The posterior column-medial lemniscus pathway, PCML for short, (also known as the dorsal column, dorsal column-medial lemniscus pathway or the dorsal white column-medial lemniscus system) is the sensory pathway responsible for transmitting fine touch, vibration and conscious proprioceptive information from the body to the cerebral cortex; as well as tactile pressure, barognosis, graphesthesia, stereognosis, recognition of texture, kinesthesia and two-point discrimination.
The name comes from the two structures that the sensation travels up: the posterior (or dorsal) columns of the spinal cord, and the medial lemniscus in the brainstem. Because the posterior columns are also called dorsal columns, the pathway is often called the dorsal column-medial lemniscus system, or DCML for short.
The PCML pathway is composed of rapidly conducting, large, myelinated fibers.
This fine sensation is detected by Meissner's corpuscles that lie in the dermis of the skin close to the epidermis. When these structures are stimulated by slight pressure, an action potential is started. Alternatively, proprioceptive muscle spindles and other skin surface touch receptors such as Merkel cells, Ruffini endings, Pacinian corpuscles, and hair follicle receptors (peritrichial endings) may involve the first neuron in this pathway.
The action potential travels up an axon (the cell body of the neuron will be in a dorsal root ganglion). (The neurons are classified as pseudo-unipolar, so they are regarded as having just one long process, which includes both a peripheral branch dendrite and central branch axon.) So the sensation travels from the skin, along the axon, past the neuronal cell body, and into the dorsal column of the spinal cord.
The axons continue inside the spinal cord, running up the posterior (dorsal) column. Axons from the lower body are most medial (closer to the midline), and run in the gracile tract of the spinal column. Sensory axons from the upper body enter the spinal cord later, specifically from T6 on up, so are more lateral and travel up the cuneate tract.
The secondary neurons (that start in the nuclei) cross over to the other side of the medulla (as internal arcuate fibres) to form the medial lemniscus. This crossing over is commonly referred to as the sensory decussation.
At the medulla, the medial lemniscus is orientated perpendicular to the way the fibres travelled in the posterior columns. For example, in the columns, lower limb is medial, upper limb is more lateral. At the medial lemniscus, axons from the leg are more ventral, and axons from the arm are more dorsal. Fibres from the trigeminal nerve (supplying the head) come in dorsal to the arm fibres, and travel up the lemniscus too.
The medial lemniscus rotates 90 degrees at the pons. The secondary axons from neurons giving sensation to the head, stay at around the same place, while the leg axons move outwards.
The axons travel up the rest of the brainstem, and synapse at the thalamus (at the ventral posterolateral nucleus for sensation from the neck, trunk, and extremities, and at the ventral posteromedial nucleus for sensation from the head).
Neurons starting in the thalamus travel up the posterior limb of the internal capsule, and again head and leg swap relative positions. The axons synapse in the primary sensory cortex, with lower body sensation most medial (e.g., the paracentral lobule) and upper body more lateral.
The pathway is tested with the Romberg's test. Lesions to the posterior column-medial lemniscus pathway below the decussation of its fibers produce loss of sensation on the same side of the body as the lesion. Above the decussation produces loss of sensation on the opposite side of the body than the lesion.
- Physiology at MCG 8/8ch5/s8ch5_22
- O'Sullivan, S. B., & Schmitz, T. J. (2007). Physical Rehabilitation (5th Edition ed.). Philadelphia: F.A. Davis Company.
- Luria, V; Laufer, E (2007 Jul 2). "Lateral motor column axons execute a ternary trajectory choice between limb and body tissues.". Neural development 2: 13. doi:10.1186/1749-8104-2-13. PMID 17605791.