The Potapoco were a group of Native Americans living in Maryland at the time of English colonization. The Potapoca were an Algonquian-speaking tribe and they inhabited the coastal area along the Port Tobacco River. They called their settlement Potopaco. Overall, the dominant tribe on the north side of the Potomac River was the Algonquian Piscataway tribe, which later absorbed some of the smaller tribes' survivors. Upon absorption, they became a sub-tribe of the Piscataway.