Tandem pore domain potassium channel

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Two-pore-domain potassium channels: This family of 15 members form what is known as "leak channels" which possess Goldman-Hodgkin-Katz (open) rectification.[1] These channels are regulated by several mechanisms including oxygen tension, pH, mechanical stretch, and G-proteins. Their name is derived from the fact that the α subunits consist of four transmembrane segments, each containing two pore loops. As such, they structurally correspond to two inward-rectifier α subunits and thus form dimers in the membrane.

Below is a list of the 15 known two-pore-domain human potassium channels:[1]

Gene Channel
KCNK1 K2p1.1
KCNK2 K2p2.1
KCNK3 K2p3.1
KCNK4 K2p4.1
KCNK5 K2p5.1
KCNK6 K2p6.1
KCNK7 K2p7.1
KCNK9 K2p9.1
KCNK10 K2p10.1
KCNK12 K2p12.1
KCNK13 K2p13.1
KCNK15 K2p15.1
KCNK16 K2p16.1
KCNK17 K2p17.1
KCNK18 K2p18.1

[edit] See also

[edit] References

  1. ^ a b Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S (2005). "International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels". Pharmacol Rev 57 (4): 527–40. doi:10.1124/pr.57.4.12. PMID 16382106. 

[edit] External links

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