Pranlukast

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Pranlukast
Pranlukast.svg
Systematic (IUPAC) name
N-[4-oxo-2-(1H-tetrazol-5-yl)-4H-chromen-7-yl]-4-(4-phenylbutoxy)benzamide
Clinical data
AHFS/Drugs.com International Drug Names
Legal status ?
Routes Oral
Pharmacokinetic data
Metabolism Hepatic (mainly CYP3A4)[1]
Half-life 1.5 hours[1]
Identifiers
CAS number 103177-37-3 YesY
ATC code R03DC02
PubChem CID 4887
DrugBank DB01411
ChemSpider 4718 YesY
UNII TB8Z891092 YesY
ChEMBL CHEMBL21333 YesY
Chemical data
Formula C27H23N5O4 
Mol. mass 481.503 g/mol
 YesY (what is this?)  (verify)

Pranlukast is a cysteinyl leukotriene receptor-1 antagonist. This drug works similarly to Merck & Co.'s Singulair (montelukast). It is widely used in Japan.

Medications of this class, which go under a variety of names according to whether one looks at the American, British or European system of nomenclature, have as their primary function the antagonism of bronchospasm caused, principally in asthmatics, by an allergic reaction to accidentally or inadvertently encountered allergens.

Medications of this group are normally used as an adjunct to the standard therapy of inhaled steroids with inhaled long- and/or short-acting beta-agonists. There are several similar medications in the group; all appear to be equally effective.

References[edit]

  1. ^ a b Nakade S, Ueda S, Ohno T, Nakayama K, Miyata Y, Yukawa E, Higuchi S (2006). "Population pharmacokinetics of pranlukast hydrate dry syrup in children with allergic rhinitis and bronchial asthma.". Drug Metab Pharmacokinet 21 (2): 133–9. doi:10.2133/dmpk.21.133. PMID 16702733.