Precursor B-cell lymphoblastic leukemia is a form of lymphoid leukemia in which too many B-cell lymphoblasts (immature white blood cells) are found in the blood and bone marrow. It is the most common type of acute lymphoblastic leukemia (ALL). It is sometimes additionally classified as a lymphoma, as designated leukemia/lymphoma.
It consists of the following subtypes:
- t(9;22)-BCR/ ABL
- t(v;11q23)-MLL rearrangement
- t(12;21)-ETV/ CBFα
One interesting model of precursor B ALL shows aberrant function of a single gene, namely Pax5, as capable to change phenotype of B cells toward precursor cells.
This article incorporates public domain material from the U.S. National Cancer Institute document "Dictionary of Cancer Terms".