Prescott is the home of Fort Wellington National Historic Site, which is a tourist destination. The Battle of the Thousand Islands was fought near the present location of the city in August 1760. During the War of 1812, troops stationed at Fort Wellington crossed the frozen river and burned Ogdensburg in retaliation for an American raid further up the river; the American citizens of Ogdensburg, who were profiting by supplying the British army with food and other necessities, drove out their own American military detachment after the raid so that they could continue doing business with the British army in Prescott.
In 1991, Prescott was the focus of a child sexual abuse scandal, as local residents Billy Elliott, his parents and several others were revealed as chronic abusers.
Prescott is home to the Sandra S. Lawn Harbour, which attracts boaters from as far east as Montreal serving as a picturesque gateway to the Thousand Islands. During the summer months, Prescott hosts the St. Lawrence Shakespeare Festival, a professional theatrical production, at the Harbour's public amphitheatre.