Pridefine

From Wikipedia, the free encyclopedia
  (Redirected from Pridefrine)
Jump to: navigation, search
Pridefine
Pridefine.png
Systematic (IUPAC) name
3-(diphenylmethylidene)-1-ethylpyrrolidine
Clinical data
Legal status
  • Uncontrolled
Routes Oral
Identifiers
CAS number 5370-41-2
ATC code None
PubChem CID 31740
ChemSpider 29434
UNII W0394470AX YesY
Chemical data
Formula C19H21N 
Mol. mass 263.38 g/mol

Pridefine (AHR-1,118) is a drug which was investigated as an antidepressant in the late 1970s and early 1980s but was never marketed.[1] It acts as a balanced reuptake inhibitor of serotonin, dopamine, and norepinephrine, and also has some weak releasing activity.[1][2][3]

In clinical trials pridefine was found to be as efficacious as the tricyclic antidepressants amitriptyline and imipramine in the treatment of major depressive disorder but was much more tolerable in comparison and also had an earlier onset of action.[1] It has been shown to be effective in the treatment of alcoholism as well.[1]

See also[edit]

References[edit]

  1. ^ a b c d Vosmer G, DeMet EM, Halaris AE (October 1980). "Action of the antidepressant pridefine (AHR-1118) on biogenic amines in the rat brain". Biochemical Pharmacology 29 (19): 2557–62. doi:10.1016/0006-2952(80)90066-0. PMID 7426062. 
  2. ^ Halaris AE, Demet EM (1980). "Open trial evaluation of a pyrrolidine derivative (AHR-1118) on norepinephrine metabolism". Progress in Neuro-psychopharmacology 4 (1): 43–9. doi:10.1016/0364-7722(80)90060-0. PMID 7406986. 
  3. ^ DeMet EM, Vosmer G, Halaris AE (March 1981). "Noncompetitive amine uptake inhibition by the new antidepressant pridefine". Journal of Neurochemistry 36 (3): 917–23. doi:10.1111/j.1471-4159.1981.tb01682.x. PMID 7205281.