Prilocaine
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-Prilocaine_Structural_Formulae.png) |
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Prilocaine
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| Systematic (IUPAC) name | |
| (RS)-N-(2-methylphenyl)-N2-propylalaninamide | |
| Identifiers | |
| CAS number | |
| ATC code | N01 |
| PubChem | |
| DrugBank | |
| Chemical data | |
| Formula | C13H20N2O |
| Mol. mass | 220.311 g/mol |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Protein binding | 55% |
| Metabolism | Hepatic and renal |
| Half life | 10-150 minutes, longer with impaired hepatic or renal function |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
B (U.S.) |
| Legal status | |
| Routes | ? |
Prilocaine (pronounced /ˈpraɪlɵkeɪn/) is a local anesthetic of the amino amide type. In its injectable form (trade name Citanest), it is often used in dentistry. It is also often combined with lidocaine as a preparation for dermal anesthesia (lidocaine/prilocaine or EMLA), for treatment of conditions like paresthesia. As it has low cardiac toxicity, it is commoly used for intravenous regional anaesthesia (IVRA).
In some patients, a metabolite of prilocaine may cause the unusual side-effect of methaemoglobinaemia. And may be treated with methylene blue.
Maximum dosage for dental use: 8.0 mg/kg (2.7 mg/lb), with a maximum dose of 500 mg.
Contents |
[edit] Toxicology
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This section requires expansion. |
[edit] Compendial status
[edit] Notes
- ^ The United States Pharmacopeial Convention. "Revision Bulletin: Lidocaine and Prilocaine Cream–Revision to Related Compounds Test". http://www.usp.org/USPNF/notices/lidocaineAndPrilocaine.html. Retrieved on 10 July 2009.
[edit] See also
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