Profenamine

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Profenamine
Profenamine.svg
Systematic (IUPAC) name
N,N-diethyl-1-(10H-phenothiazin-10-yl)propan-2-amine
Clinical data
AHFS/Drugs.com International Drug Names
Legal status
?
Pharmacokinetic data
Protein binding 93%
Half-life 1 to 2 hours
Identifiers
CAS number 1094-08-2 YesY
ATC code N04AA05
PubChem CID 3290
DrugBank DB00392
ChemSpider 3174 YesY
UNII O00T1I1VRN YesY
ChEBI CHEBI:313639 YesY
ChEMBL CHEMBL1206 YesY
Chemical data
Formula C19H24N2S 
Mol. mass 312.473 g/mol
 YesY (what is this?)  (verify)

Profenamine (INN, trade names Parsidol, Parsidan, Parkin), also known as ethopropazine (BAN), is a phenothiazine derivative used as an antiparkinsonian agent that has anticholinergic, antihistamine, and antiadrenergic actions. It is also used in the alleviation of the extrapyramidal syndrome induced by drugs such as other phenothiazine compounds, but, like other compounds with antimuscarinic properties, is of no value against tardive dyskinesia.

Synthesis[edit]

Ethopropazine, 10-(2-diethylaminopropyl) phenothiazine, is synthesized by alkylation of phenothiazine using 2-chloro-1-(diethylamino)propane in the presence of sodium amide.

P. Carpentier, U.S. Patent 2,526,118 (1950). S.S. Berg, J.N. Ashley, U.S. Patent 2,607,773 (1952).

References[edit]