Proflavine

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Proflavine
Proflavine structure.png
Identifiers
CAS number 92-62-6 YesY
PubChem 7099
ChemSpider 6832 YesY
UNII CY3RNB3K4T YesY
DrugBank DB01123
KEGG C11181 YesY
ChEBI CHEBI:8452 YesY
ChEMBL CHEMBL55400 YesY
Jmol-3D images Image 1
Properties
Molecular formula C13H11N3
Molar mass 209.25 g mol−1
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 YesY (verify) (what is: YesY/N?)
Infobox references

Proflavine (pron. pro-fla¢vin), also called proflavin and diaminoacridine, is an acriflavine derivative, a disinfectant bacteriostatic against many gram-positive bacteria. It has been used in the form of the dihydrochloride and hemisulfate salts as a topical antiseptic, and was formerly used as a urinary antiseptic.

Proflavine is also known to have a mutagenic effect on DNA by intercalating between nucleic acid base pairs. It differs from most other mutagenic components by causing basepair-deletions or basepair-insertions and not substitutions.

Proflavine absorbs strongly in the blue region at 445 nm (in water at pH 7) with molar extinction coefficient of c. 40,000[1]

References[edit]

  1. ^ Sarre, Peter J. (2006). "The Diffuse Interstellar Bands: A Major Problem in Astronomical Spectroscopy". arXiv:astro-ph/0608113.