Progress M-03M launched on a Soyuz-U carrier rocket, flying from Site 1/5 at the Baikonur Cosmodrome. Liftoff took place at 01:14 UTC on 15 October 2009. Docking with the Pirs module of the ISS took place on 18 October at 01:40 UTC. Progress M-03M delivered 790 kilograms (1750 lb) of dry cargo, 870 kg (1918 lb) of propellant and 420 kg (926 lb) of water.
The spacecraft undocked from Pirs on 22 April 2010. Filled with trash and discarded space station items, the Progress ship was used for scientific experiments until it was deorbited, entering the Earth's atmosphere and burning up over the Pacific ocean. The deorbit burn occurred at 18:07 UTC on 27 April 2010.
Payloads are separated by bullets ( · ), launches by pipes ( | ). Manned flights are indicated in bold text. Uncatalogued launch failures are listed in italics. Payloads deployed from other spacecraft are denoted in brackets.