Progress M-16 was a Russian unmanned cargo spacecraft which was launched in 1993 to resupply the Mir space station. The thirty-fourth of sixty-four Progress spacecraft to visit Mir, it used the Progress-M 11F615A55 configuration, and had the serial number 216. It carried supplies including food, water and oxygen for the EO-13 crew aboard Mir, as well as equipment for conducting scientific research, and fuel for adjusting the station's orbit and performing manoeuvres.
Progress M-16 was launched at 18:32:32 GMT on 21 February 1993, atop a Soyuz-U2 carrier rocket flying from Site 1/5 at the Baikonur Cosmodrome. Following two days of free flight, it docked with the aft port of the Kvant-1 module at 20:17:57 GMT on 23 February.
Progress M-16 remained docked with Mir for 30 days, during which time it was in an orbit of around 387 by 390 kilometres (209 by 211 nmi), inclined at 51.6 degrees. It undocked from Mir at 06:50:00 GMT on 26 March, before redocking with the same port at 07:06:03 to test its docking systems. It undocked for the final time at 04:21:00 GMT on 27 March, and was deorbited few hours later at 10:25:00, to a destructive reentry over the Pacific Ocean.
Payloads are separated by bullets ( · ), launches by pipes ( | ). Manned flights are indicated in bold text. Uncatalogued launch failures are listed in italics. Payloads deployed from other spacecraft are denoted in brackets.