Progress M-50 was launched by a Soyuz-U carrier rocket from Site 1/5 at the Baikonur Cosmodrome. Launch occurred at 05:03:07 GMT on 11 August 2004. The spacecraft docked with the Aft port of the Zvezda module at 05:01:08 GMT on 14 August. It remained docked for four months before undocking at 19:37:02 GMT on 22 December 2004 to make way for Progress M-51. It was deorbited at 22:32:06 GMT on 22 December 2004. The spacecraft burned up in the atmosphere over the Pacific Ocean, with any remaining debris landing in the ocean at around 23:23:38 GMT.
Progress M-50 carried supplies to the International Space Station, including food, water and oxygen for the crew and equipment for conducting scientific research.
Payloads are separated by bullets ( · ), launches by pipes ( | ). Manned flights are indicated in bold text. Uncatalogued launch failures are listed in italics. Payloads deployed from other spacecraft are denoted in brackets.