Progress M1-6 was launched on the maiden flight of the Soyuz-FG carrier rocket, flying from Site 1/5 at the Baikonur Cosmodrome. Launch occurred at 22:32:40 GMT on 20 May 2001. The spacecraft docked with the Aft port of the Zvezda module at 00:23:57 GMT on 23 May. It remained docked for three months before undocking at 06:02 GMT on 22 August to make way for Progress M-45. It was deorbited at 09:00 GMT on the same day, burning up in the atmosphere over the Pacific Ocean, with any remaining debris landing in the ocean at around 09:50 GMT.
Progress M1-6 carried supplies to the International Space Station, including food, water and oxygen for the crew and equipment for conducting scientific research.
Payloads are separated by bullets ( · ), launches by pipes ( | ). Manned flights are indicated in bold text. Uncatalogued launch failures are listed in italics. Payloads deployed from other spacecraft are denoted in brackets.