Prokaryotic elongation factors

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EF-Tu was PDB Molecule of the Month pdb81_1 on September 2006

In prokaryotes, three elongation factors are required for translation: EF-Tu, EF-Ts, and EF-G.

  • EF-Tu (elongation factor thermo unstable) mediates the entry of the aminoacyl tRNA into a free site of the ribosome.
  • EF-Ts serves as the guanine nucleotide exchange factor for EF-Tu, catalyzing the release of GDP from EF-Tu.
  • EF-G catalyzes the translocation of the tRNA and mRNA down the ribosome at the end of each round of polypeptide elongation.

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