Proline—tRNA ligase

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proline—tRNA ligase
Identifiers
EC number 6.1.1.15
CAS number 9055-68-9
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a proline—tRNA ligase (EC 6.1.1.15) is an enzyme that catalyzes the chemical reaction

ATP + L-proline + tRNAPro \rightleftharpoons AMP + diphosphate + L-prolyl-tRNAPro

The 3 substrates of this enzyme are ATP, L-proline, and tRNA(Pro), whereas its 3 products are AMP, diphosphate, and L-prolyl-tRNA(Pro).

This enzyme belongs to the family of ligases, to be specific those forming carbon-oxygen bonds in aminoacyl-tRNA and related compounds. The systematic name of this enzyme class is L-proline:tRNAPro ligase (AMP-forming). Other names in common use include prolyl-tRNA synthetase, prolyl-transferRNA synthetase, prolyl-transfer ribonucleate synthetase, proline translase, prolyl-transfer ribonucleic acid synthetase, prolyl-s-RNA synthetase, and prolinyl-tRNA ligase. This enzyme participates in arginine and proline metabolism and aminoacyl-trna biosynthesis.

Structural studies[edit]

As of late 2007, 15 structures have been solved for this class of enzymes, with PDB accession codes 1H4Q, 1H4S, 1H4T, 1HC7, 1NJ1, 1NJ2, 1NJ5, 1NJ6, 1NJ8, 2I4L, 2I4M, 2I4N, 2I4O, 2J3L, and 2J3M.

References[edit]