This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with 2-oxoglutarate as one donor, and incorporation of one atom o oxygen into each donor. The systematic name of this enzyme class is procollagen-L-proline,2-oxoglutarate:oxygen oxidoreductase (4-hydroxylating). Other names in common use include protocollagen hydroxylase, proline hydroxylase, proline,2-oxoglutarate 4-dioxygenase, collagen proline hydroxylase, hydroxylase, collagen proline, peptidyl proline hydroxylase, proline protocollagen hydroxylase, proline, 2-oxoglutarate dioxygenase, prolyl hydroxylase, prolylprotocollagen dioxygenase, prolylprotocollagen hydroxylase, protocollagen proline 4-hydroxylase, protocollagen proline dioxygenase, protocollagen proline hydroxylase, protocollagen prolyl hydroxylase, prolyl 4-hydroxylase, prolyl-glycyl-peptide, 2-oxoglutarate:oxygen oxidoreductase,, 4-hydroxylating, and procollagen-proline 4-dioxygenase. This enzyme participates in arginine and proline metabolism. It has 2 cofactors: iron, and Ascorbate.
Berg RA, Prockop DJ (1973). "Affinity column purification of protocollagen proline hydroxylase from chick embryos and further characterization of the enzyme". J. Biol. Chem.248 (4): 1175–82. PMID4346946.
Hutton JJ, Jr, Tappel AL and Udenfriend S (1967). "Cofactor and substrate requirements of collagen proline hydroxylase". Arch. Biochem. Biophys.118 (1): 231–240. doi:10.1016/0003-9861(67)90302-5.
Kivirikko KI, Kishida Y, Sakakibara S, Prockop DJ (1972). "Hydroxylation of (X-Pro-Gly)n by protocollagen proline hydroxylase Effect of chain length, helical conformation and amino acid sequence in the substrate". Biochim. Biophys. Acta.271 (2): 347–56. PMID5046811.
Kivirikko KI and Prockop DJ (1967). "Purification and partial characterization of the enzyme for the hydroxylation of proline in protocollogen". Arch. Biochem. Biophys.118 (3): 611–618. doi:10.1016/0003-9861(67)90396-7.