Promazine

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Promazine
Promazine.svg
Promazine3d.png
Systematic (IUPAC) name
N,N-dimethyl-3-(10H-phenothiazin-10-yl)-propan-1-amine
Clinical data
AHFS/Drugs.com Micromedex Detailed Consumer Information
MedlinePlus a600010
Legal status ?
Pharmacokinetic data
Protein binding 94%
Identifiers
CAS number 58-40-2 YesY
ATC code N05AA03
PubChem CID 4926
DrugBank DB00420
ChemSpider 4757 YesY
UNII O9M39HTM5W YesY
ChEBI CHEBI:8459 YesY
ChEMBL CHEMBL564 YesY
Chemical data
Formula C17H20N2S 
Mol. mass 284.42 g/mol
 YesY (what is this?)  (verify)

Promazine (Sparine) is a medication that belongs to the phenothiazine class of antipsychotics. An older medication used to treat schizophrenia, it is still prescribed, alongside newer agents such as olanzapine and quetiapine. It has predominantly anticholinergic side effects, though extrapyramidal side effects are not uncommon either.

Promazine is not approved for human use in the United States. It is available in the US for veterinary use under the names Promazine and Tranquazine.

Chemistry[edit]

Promazine, 10-(3-dimethylaminopropyl)phenothiazine, is prepared by the alkylation of phenothiazine with 3-dimethylaminopropylchloride in the presence of sodamide. Promazine synthesis.png

Diethazine[edit]

A related drug, diethazine, is synthesized as follows: Ethazine.png Charpentier, P.; Cmpt. Rend. 1947, 225, 306.


See also[edit]

References[edit]

  1. ^ doi:10.1021/ja01189a079
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