Propionic anhydride
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(Redirected from Propanoic anhydride)
| Propanoic anhydride | |
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Propanoyl propanoate |
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Other names
Propanoic anhydride |
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| Identifiers | |
| CAS number | 123-62-6  |
| RTECS number | UF9100000 |
| Properties | |
| Molecular formula | C6H10O3 |
| Molar mass | 130.14 g/mol |
| Appearance | Clear liquid, with a strong smell similar to vinegar |
| Density | 1.015 g/cm³, liquid |
| Melting point |
−42 °C |
| Boiling point |
167–170 °C |
| Solubility in water | Reacts to give propanoic acid |
| Viscosity | 1.144 cP at ?°C |
| Hazards | |
| MSDS | External MSDS |
| R-phrases | R34 |
| S-phrases | S26-45 |
| Main hazards | flammable |
| Flash point | 63 °C |
| Related compounds | |
| Related compounds | Acetic anhydride |
 (verify) (what is:  / ?)Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) |
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| Infobox references | |
Propanoic anhydride is an organic compound with the formula (CH3CH2CO)2O. This simple acid anhydride is a colourless liquid.. It is a widely used reagent in organic synthesis.
Contents |
[edit] Synthesis
Propanoic anhydride has been prepared by dehydration of propanoic acid using ketene:[1]
- 2 CH3CH2CO2H + CH2=C=O → (CH3CH2CO)2O + CH3CO2H
[edit] Safety
Propanoic anhydride is strong smelling and corrosive, and will cause burns on contact with skin. Vapour can burn eyes and lungs.
[edit] Legal Status
Due to its potential use as a precursor in the synthesis of fentanyl and fentanyl analogs, propanoic anhydride is regulated by the United States Drug Enforcement Agency as a List I chemical under the Controlled Substances Act.[2]
[edit] References
- ^ Williams, J. W. Krynitsky, J. A. (1955), "n-Caproic Anhydride", Org. Synth., http://www.orgsyn.org/orgsyn/orgsyn/prepContent.asp?prep=cv3p0164; Coll. Vol. 3
- ^ Drugs of Abuse Publication, Chapter 2
