Prostaglandin-A1 Delta-isomerase

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prostaglandin-A1 delta-isomerase
Identifiers
EC number 5.3.3.9
CAS number 9055-01-0
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a prostaglandin-A1 Delta-isomerase (EC 5.3.3.9) is an enzyme that catalyzes the chemical reaction

(13E)-(15S)-15-hydroxy-9-oxoprosta-10,13-dienoate \rightleftharpoons (13E)-(15S)-15-hydroxy-9-oxoprosta-11,13-dienoate

Hence, this enzyme has one substrate, (13E)-(15S)-15-hydroxy-9-oxoprosta-10,13-dienoate (Prostaglandin A1 or PGA1), and one product, (13E)-(15S)-15-hydroxy-9-oxoprosta-11,13-dienoate (Prostaglandin C1).

This enzyme belongs to the family of isomerases, specifically those intramolecular oxidoreductases transposing C=C bonds. The systematic name of this enzyme class is (13E)-(15S)-15-hydroxy-9-oxoprosta-10,13-dienoate Delta10-Delta11-isomerase. This enzyme is also called prostaglandin A isomerase.

References[edit]

  • Polet H, Levine L (1975). "Metabolism of prostaglandins E, A, and C in serum". J. Biol. Chem. 250 (2): 351–7. PMID 234423.