Prostaglandin-D synthase

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prostaglandin-D synthase
Protein PTGDS PDB 2WWP.png
Human Prostaglandin-D2 synthase. PDB 2wwp
Identifiers
EC number 5.3.99.2
CAS number 65802-85-9
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a prostaglandin-D synthase (EC 5.3.99.2) is an enzyme that catalyzes the chemical reaction

(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13- dienoate \rightleftharpoons (5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate

Thus, the substrate of this enzyme is (5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate, whereas its product is (5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate.

This enzyme belongs to the family of isomerases, specifically a class of other intramolecular oxidoreductases. The systematic name of this enzyme class is (5,13)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate Delta-isomerase. Other names in common use include prostaglandin-H2 Delta-isomerase, prostaglandin-R-prostaglandin D isomerase, and PGH-PGD isomerase. This enzyme participates in arachidonic acid metabolism.

In March 2012 American scientists reported a discovery that shows this enzyme triggers male baldness[1] According to the discovery, levels of this enzyme are elevated in the cells of hair follicles located in bald patches on the scalp, but not in hairy areas. The research could lead to a cream to treat baldness.


Structural studies[edit]

As of late 2001, 7 structures have been solved for this class of enzymes, with PDB accession codes 1IYH, 1IYI, 1PD2, 1V40, 2CZT, 2CZU, and 2E4J.


See also[edit]

Prostaglandin D2 synthase

Hematopoietic prostaglandin D synthase

References[edit]

  1. ^ Garza, L. A.; Liu, Y.; Yang, Z.; Alagesan, B.; Lawson, J. A.; Norberg, S. M.; Loy, D. E.; Zhao, T.; Blatt, H. B.; Stanton, D. C.; Carrasco, L.; Ahluwalia, G.; Fischer, S. M.; Fitzgerald, G. A.; Cotsarelis, G. (2012). "Prostaglandin D2 Inhibits Hair Growth and is Elevated in Bald Scalp of Men with Androgenetic Alopecia". Science Translational Medicine 4 (126): 126ra34. doi:10.1126/scitranslmed.3003122. PMC 3319975. PMID 22440736.  edit
  • Christ-Hazelhof E, Nugteren DH (1979). "Purification and characterisation of prostaglandin endoperoxide D-isomerase, a cytoplasmic, glutathione-requiring enzyme". Biochim. Biophys. Acta. 572 (1): 43–51. doi:10.1016/0005-2760(79)90198-x. PMID 32914. 
  • Shimizu T, Yamamoto S, Hayaishi O (1979). "Purification and properties of prostaglandin D synthetase from rat brain". J. Biol. Chem. 254 (12): 5222–8. PMID 109431. 
  • Sri Kantha,S. Prostaglandin D syntha (beta-trace protein) - a molecular clock to trace the origin of REM sleep? Medical Hypotheses, 1997; 48: 411-412.