Prostaglandin E synthase
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(Redirected from Prostaglandin E2 synthase)
| prostaglandin-E synthase | |||||||
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| Identifiers | |||||||
| EC number | 5.3.99.3 | ||||||
| CAS number | 52227-79-9 | ||||||
| Databases | |||||||
| IntEnz | IntEnz view | ||||||
| BRENDA | BRENDA entry | ||||||
| ExPASy | NiceZyme view | ||||||
| KEGG | KEGG entry | ||||||
| MetaCyc | metabolic pathway | ||||||
| PRIAM | profile | ||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||
| Gene Ontology | AmiGO / EGO | ||||||
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Prostaglandin E synthase (or PGE synthase) is an enzyme involved in eicosanoid and glutathione metabolism, a member of MAPEG family. It generates prostaglandin E (PGE) from prostaglandin H2.[1][2]
The synthase generating PGE2 is a membrane-associated protein.
[edit] Isozymes
Humans express three prostaglandin-E synthase isozymes, each encoded by a separate gene:
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[edit] References
- ^ Murakami M, Nakatani Y, Tanioka T, Kudo I (August 2002). "Prostaglandin E synthase". Prostaglandins Other Lipid Mediat. 68-69: 383–99. doi:10.1016/S0090-6980(02)00043-6. PMID 12432931.
- ^ Park JY, Pillinger MH, Abramson SB (June 2006). "Prostaglandin E2 synthesis and secretion: the role of PGE2 synthases". Clin. Immunol. 119 (3): 229–40. doi:10.1016/j.clim.2006.01.016. PMID 16540375.
[edit] External links
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