In medicine, a prosthesis, (from Ancient Greek prósthesis, "addition, application, attachment") is an artificial device that replaces a missing body part, which may be lost through trauma, disease, or congenital conditions. Prosthetic amputee rehabilitation is primarily coordinated by a prosthetist and an inter-disciplinary team of health care professionals including surgeons, physical therapists, and occupational therapists.
- 1 Types
- 2 History
- 3 Patient Procedure
- 4 Current technology/manufacturing
- 4.1 Body-powered arms
- 4.2 Lower extremity prosthetics
- 4.3 Myoelectric
- 4.4 Robotic prostheses
- 5 Attachment to the body
- 6 Cosmesis
- 7 Cognition
- 8 Prosthetic enhancement
- 9 Design considerations
- 10 Cost
- 11 Low-cost prosthetics for children
- 12 References
- 13 External links
A person's prosthesis should be designed and assembled according to the patient's appearance and functional needs. For instance, a patient may need a transradial prosthesis, but need to choose between an aesthetic functional device, a myoelectric device, a body-powered device, or an activity specific device. The patient's future goals and economical capabilities may help them choose between one or more devices.
Craniofacial prostheses include intra-oral and extra-oral prostheses. Extra-oral prostheses are further divided into hemifacial, auricular (ear), nasal, orbital and ocular. Intra-oral prostheses include dental prostheses such as dentures, obturators, and dental implants.
Limb prostheses include both upper and lower extremity prostheses.
Upper extremity prostheses are used at varying levels of amputation: forequarter, shoulder disarticulation, transhumeral prosthesis, elbow disarticulation, transradial prosthesis, wrist disarticulation, full hand, partial hand, finger, partial finger.
A transradial prosthesis is an artificial limb that replaces an arm missing below the elbow. Two main types of prosthetics are available. Cable operated limbs work by attaching a harness and cable around the opposite shoulder of the damaged arm. The other form of prosthetics available are myoelectric arms. wThese work by sensing, via electrodes, when the muscles in the upper arm move, causing an artificial hand to open or close. In the prosthetic industry a trans-radial prosthetic arm is often referred to as a "BE" or below elbow prosthesis.
Lower extremity prostheses provide replacements at varying levels of amputation. These include hip disarticulation, transfemoral prosthesis, knee disarticulation, transtibial prosthesis, Syme's amputation, foot, partial foot, and toe. The two main subcategories of lower extremity prosthetic devices are trans-tibial (any amputation transecting the tibia bone or a congenital anomaly resulting in a tibial deficiency) and trans-femoral (any amputation transecting the femur bone or a congenital anomaly resulting in a femoral deficiency).
A transfemoral prosthesis is an artificial limb that replaces a leg missing above the knee. Transfemoral amputees can have a very difficult time regaining normal movement. In general, a transfemoral amputee must use approximately 80% more energy to walk than a person with two whole legs. This is due to the complexities in movement associated with the knee. In newer and more improved designs, hydraulics, carbon fiber, mechanical linkages, motors, computer microprocessors, and innovative combinations of these technologies are employed to give more control to the user. In the prosthetic industry a trans-femoral prosthetic leg is often referred to as an "AK" or above the knee prosthesis.
A transtibial prosthesis is an artificial limb that replaces a leg missing below the knee. Transtibial amputees are usually able to regain normal movement more readily than someone with a transfemoral amputation, due in large part to retaining the knee, which allows for easier movement. Lower extremity prosthetics describes artificially replaced limbs located at the hip level or lower. In the prosthetic industry a trans-tibial prosthetic leg is often referred to as a "BK" or below the knee prosthesis.
Prosthetics have been mentioned throughout history. The earliest recorded mention is the warrior queen Vishpala in the Rigveda. The Egyptians were early pioneers of the idea, as shown by the wooden toe found on a body from the New Kingdom. Roman bronze crowns have also been found, but their use could have been more aesthetic than medical.
An early mention of a prosthetic comes from the Greek historian Herodotus, who tells the story of Hegesistratus, a Greek diviner who cut off his own foot to escape his Spartan captors and replaced it with a wooden one.
Wood and metal hands
Pliny the Elder also recorded the tale of a Roman general, Marcus Sergius, whose right hand was cut off while campaigning and had an iron hand made to hold his shield so that he could return to battle. A famous and quite refined historical prosthetic arm was that of Götz von Berlichingen, made at the beginning of the 16th century.
Around the same time, François de la Noue is also reported to have had an iron hand, as is, in the 17th Century, René-Robert Cavalier de la Salle. During the Middle Ages, prosthetics remained quite basic in form. Debilitated knights would be fitted with prosthetics so they could hold up a shield. Only the wealthy could afford anything that would assist in daily life. During the Renaissance, prosthetics developed with the use of iron, steel, copper, and wood. Functional prosthetics began to make an appearance in the 1500s.
Technology progress before the 20th century
An Italian surgeon recorded the existence of an amputee who had an arm that allowed him to remove his hat, open his purse, and sign his name. Improvement in amputation surgery and prosthetic design came at the hands of Ambroise Paré. Among his inventions was an above-knee device that was a kneeling peg leg and foot prosthesis with a fixed position, adjustable harness, and knee lock control. The functionality of his advancements showed how future prosthetics could develop.
Other major improvements before the modern era:
- Pieter Verduyn – First nonlocking below-knee (BK) prosthesis.
- James Potts – Prosthesis made of a wooden shank and socket, a steel knee joint and an articulated foot that was controlled by catgut tendons from the knee to the ankle. Came to be known as “Anglesey Leg” or “Selpho Leg.”
- Sir James Syme – A new method of ankle amputation that did not involve amputating at the thigh.
- Benjamin Palmer – Improved upon the Selpho leg. Added an anterior spring and concealed tendons to simulate natural-looking movement.
- Dubois Parmlee – Created prosthetic with a suction socket, polycentric knee, and multi-articulated foot.
- Marcel Desoutter & Charles Desoutter – First aluminium prosthesis
At the end of World War II, the NAS (National Academy of Sciences) began to advocate better research and development of prosthetics. Through government funding, a research and development program was developed within the Army, Navy, Air Force, and the Veterans Administration.
Lower extremity modern history
Socket technology for lower extremity limbs saw a revolution of advancement during the 1980s when John Sabolich C.P.O., invented the Contoured Adducted Trochanteric-Controlled Alignment Method (CATCAM) socket, later to evolve into the Sabolich Socket. He followed the direction of Ivan Long and Ossur Christensen as they developed alternatives to the quadrilateral socket, which in turn followed the open ended plug socket, created from wood. The advancement was due to the difference in the socket to patient contact model. Prior to this, sockets were made in the shape of a square shape with no specialized containment for muscular tissue. New designs thus help to lock in the bony anatomy, locking it into place and distributing the weight evenly over the existing limb as well as the musculature of the patient. Ischial containment is well known and used today by many prosthetist to help in patient care. Variation’s of the ischial containment socket thus exists and each socket is tailored to the specific needs of the patient. Others who contributed to socket development and changes over the years include Tim Staats, Chris Hoyt, and Frank Gottschalk. Gottschalk disputed the efficacy of the CAT-CAM socket- insisting the surgical procedure done by the amputation surgeon was most important to prepare the amputee for good use of a prosthesis of any type socket design.
The first microprocessor-controlled prosthetic knees became available in the early 1990s. The Intelligent Prosthesis was first commercially available microprocessor controlled prosthetic knee. It was released by Chas. A. Blatchford & Sons, Ltd., of Great Britain, in 1993 and made walking with the prosthesis feel and look more natural. An improved version was released in 1995 by the name Intelligent Prosthesis Plus. Blatchford released another prosthesis, the Adaptive Prosthesis, in 1998. The Adaptive Prosthesis utilized hydraulic controls, pneumatic controls, and a microprocessor to provide the amputee with a gait that was more responsive to changes in walking speed. Cost analysis reveals that a sophisticated above knee prosthesis will be in the neighborhood of $1 million in 45 years, given only annual cost of living adjustments.
A prosthesis is a functional replacement for an amputated or congenitally malformed or missing limb. Prosthetists are responsible for the prescription, design and management of a prosthetic device.
In most cases, the prosthetist begins by taking a plaster cast of the patient’s affected limb. Lightweight, high-strength thermoplastics are custom-formed to this model of the patient. Cutting-edge materials such as carbon fiber, titanium and Kevlar® provide strength and durability while making the new prosthesis lighter. More sophisticated prostheses are equipped with advanced electronics, providing additional stability and control.
Over the years there have been significant advancements in artificial limbs. New plastics and other materials, such as carbon fiber, have allowed artificial limbs to be stronger and lighter, limiting the amount of extra energy necessary to operate the limb. This is especially important for transfemoral amputees. Additional materials have allowed artificial limbs to look much more realistic, which is important to transradial and transhumeral amputees because they are more likely to have the artificial limb exposed.
In addition to new materials, the use of electronics has become very common in artificial limbs. Myoelectric limbs, which control the limbs by converting muscle movements to electrical signals, have become much more common than cable operated limbs. Myoelectric signals are picked up by electrodes, the signal gets integrated and once it exceeds a certain threshold, the prosthetic limb control signal is triggered which is why inherently, all myoelectric controls lag. Conversely, cable control is immediate and physical, and through that offers a certain degree of direct force feedback that myoelectric control does not. Computers are also used extensively in the manufacturing of limbs. Computer Aided Design and Computer Aided Manufacturing are often used to assist in the design and manufacture of artificial limbs.
Most modern artificial limbs are attached to the stump of the amputee by belts and cuffs or by suction. The stump either directly fits into a socket on the prosthetic, or—more commonly today—a liner is used that then is fixed to the socket either by vacuum (suction sockets) or a pin lock. Liners are soft and by that, they can create a far better suction fit than hard sockets. Silicone liners can be obtained in standard sizes, mostly with a circular (round) cross section, but for any other stump shape, custom liners can be made. The socket is custom made to fit the residual limb and to distribute the forces of the artificial limb across the area of the stump (rather than just one small spot), which helps reduce wear on the stump. The custom socket is created by taking a plaster cast of the stump or, more commonly today, of the liner worn over the stump, and then making a mold from the plaster cast. Newer methods include laser guided measuring which can be input directly to a computer allowing for a more sophisticated design.
One problem with the stump and socket attachment is that a bad fit will reduce the area of contact between the stump and socket or liner, and increase pockets between stump skin and socket or liner. Pressure then is higher, which can be painful. Air pockets can allow sweat to accumulate that can soften the skin. Ultimately, this is a frequent cause for itchy skin rashes. Further down the road, it can cause breakdown of the skin.
Artificial limbs are typically manufactured using the following steps:
- Measurement of the stump
- Measurement of the body to determine the size required for the artificial limb
- Fitting of a silicone liner
- Creation of a model of the liner worn over the stump
- Formation of thermoplastic sheet around the model – This is then used to test the fit of the prosthetic
- Formation of permanent socket
- Formation of plastic parts of the artificial limb – Different methods are used, including vacuum forming and injection molding
- Creation of metal parts of the artificial limb using die casting
- Assembly of entire limb
Current high tech allows body powered arms to weigh around one-half to one-third of what a myoelectric arm does.
Current body powered arms contain sockets that are built from hard epoxy or carbon fiber. These sockets or "interfaces" can be made more comfortable by lining them with a softer, compressible foam material that provides padding for the bone prominences. A self suspending or supra-condylar socket design is useful for those with short to mid range below elbow absence. Longer limbs may require the use of a locking roll-on type inner liner or more complex harnessing to help augment suspension.
Wrist units are either screw-on connectors featuring the UNF 1/2-20 thread (USA) or quick release connector, of which there are different models.
Voluntary opening and voluntary closing
Two types of body powered systems exist, voluntary opening "pull to open" and voluntary closing "pull to close". Virtually all "split hook" prostheses operate with a voluntary opening type system.
More modern "prehensors" called GRIPS utilize voluntary closing systems. The differences are significant. Users of voluntary opening systems rely on elastic bands or springs for gripping force, while users of voluntary closing systems rely on their own body power and energy to create gripping force.
Voluntary closing users can generate prehension forces equivalent to the normal hand, upwards to or exceeding one hundred pounds. Voluntary closing GRIPS require constant tension to grip, like a human hand, and in that property they do come closer to matching human hand performance. Voluntary opening split hook users are limited to forces their rubber or springs can generate which usually is below twenty pounds.
An additional difference exists in the biofeedback created that allows the user to "feel" what is being held. Voluntary opening systems once engaged provide the holding force so that they operate like a passive vice at the end of the arm. No gripping feedback is provided once the hook has closed around the object being held. Voluntary closing systems provide directly proportional control and biofeedback so that the user can feel how much force that they are applying.
A recent study showed that by stimulating the median and ulnar nerves, according to the information provided by the artificial sensors from a hand prosthesis, physiologically appropriate (near-natural) sensory information could be provided to an amputee. This feedback enabled the participant to effectively modulate the grasping force of the prosthesis with no visual or auditory feedback.
Researchers from Ècole Polytechnique Fédéral De Lausanne, in Switzerland and the Scuola Superiore Sant'Anna, in Italy, implanted the electrodes into the amputee's arm in February 2013. The study, published Wednesday in Science Translational Medicine, details the first time sensory feedback has been restored allowing an amputee to control an artificial limb in real-time. With wires linked to nerves in his upper arm, the Danish patient was able to handle objects and instantly receive a sense of touch through the special artificial hand that was created by Silvestro Micera and researchers both in Switzerland and Italy.
Terminal devices contain a range of hooks, prehensors, hands or other devices.
Voluntary opening split hook systems are simple, convenient, light, robust, versatile and relatively affordable. Hooks obviously do not match human hand in both appearance and overall versatility.
However, a hook's material tolerances can also exceed and surpass the human hand for mechanical stress (one can use a hook to slice open boxes or as a hammer whereas same is not possible with a hand), for thermal stability (one can use a hook to grip items from boiling water, to turn meat on a grill, to hold a match until it has burned down completely) and for chemical hazards (as a metal hook withstands acids or lye, and does not react to solvents as a prosthetic glove or human skin does).
Prosthetic hands are available in both voluntary opening and voluntary closing versions and because of their more complex mechanics and cosmetic glove covering require a relatively large activation force, which, depending on the type of harness used, may be uncomfortable. A recent study by the Delft University of Technology, The Netherlands, showed that the development of mechanical prosthetic hands has been neglected during the past decades. The study showed that the pinch force level of most current mechanical hands is too low for practical use. The best tested hand was a prosthetic hand developed around 1945.
Commercial providers, materials
Hosmer and Otto Bock are major commercial hook providers. Mechanical hands are sold by Hosmer and Otto Bock as well; the Becker Hand is still manufactured by the Becker family. Prosthetic hands may be fitted with standard stock or custom made cosmetic looking silicone gloves. But regular work gloves may be worn as well. Other terminal devices include the V2P Prehensor, a versatile robust gripper that allows customers to modify aspects of it, Texas Assist Devices (with a whole assortment of tools) and TRS that offers a range of terminal devices for sports. Cable harnesses can be built using aircraft steel cables, ball hinges and self lubricating cable sheaths.
Lower extremity prosthetics
Lower extremity prosthetics describes artificially replaced limbs located at the hip level or lower. Concerning all ages Ephraim et al. (2003) found a worldwide estimate of all-cause lower-extremity amputations of 2.0 – 5.9 per 10.000 inhabitants. For birth prevalence rates of congenital limb deficiency they found an estimate between 3.5 – 7.1 cases per 10.000 births.
The two main subcategories of lower extremity prosthetic devices are 1.trans-tibial (any amputation transecting the tibia bone or a congenital anomaly resulting in a tibial deficiency) and 2.trans-femoral (any amputation transecting the femur bone or a congenital anomaly resulting in a femoral deficiency). In the prosthetic industry a trans-tibial prosthetic leg is often referred to as a "BK" or below the knee prosthesis while the trans-femoral prosthetic leg is often referred to as an "AK" or above the knee prosthesis.
Other, less prevalent lower extremity cases include the following:
- Hip disarticulations – This usually refers to when an amputee or congenitally challenged patient has either an amputation or anomaly at or in close proximity to the hip joint.
- Knee disarticulations – This usually refers to an amputation through the knee disarticulating the femur from the tibia.
- Symes – This is an ankle disarticulation while preserving the heel pad.
This important part serves as an interface between the residuum and the prosthesis, allowing comfortable weight-bearing, movement control and proprioception. Its fitting is one of the most challenging aspects of the entire prosthesis. The difficulties accompanied with the socket are that it needs to have a perfect fit, with total surface bearing to prevent painful pressure spots. It needs to be flexible, but sturdy, to allow normal gait movement but not bend under pressure.
Shank & connectors
This part creates distance and support between the knee-joint and the foot (in case of upper-leg prosthesis) or between the socket and the foot. The type of connectors that are used between the shank and the knee/foot determines whether the prosthesis is modular or not. Modular means that the angle and the displacement of the foot in respect to the socket can be changed after fitting. In developing countries prosthesis mostly are non-modular, in order to reduce cost. When considering children modularity of angle and height is important because of their average growth of 1.9 cm annually.
Providing contact to the ground, the foot provides shock absorption and stability during stance. Additionally it influences gait biomechanics by its shape and stiffness. This is because the trajectory of the center of pressure (COP) and the angle of the ground reaction forces is determined by the shape and stiffness of the foot and needs to match the subjects build in order to produce a normal gait pattern. Andrysek (2010) found 16 different types of feet, with greatly varying results concerning durability and biomechanics. The main problem found in current feet is durability, endurance ranging from 16–32 months  These results are for adults and will probably be worse for children due to higher activity levels and scale effects.
In case of a trans-femoral amputation there also is a need for a complex connector providing articulation, allowing flexion during swing-phase but not during stance.
To mimic the knee's functionality during gait, microprocessor-controlled knee joints have been developed that control the flexion of the knee. Some examples are Otto Bock’s C-leg , introduced in 1997, Ossur's Rheo Knee, released in 2005, the Power Knee by Ossur, introduced in 2006, the Plié Knee from Freedom Innovations and DAW Industries’ Self Learning Knee (SLK).
A microprocessor is used to interpret and analyse signals from knee-angle sensors and moment sensors. The microprocessor receives signals from its sensors to determine the type of motion being employed by the amputee. Most microprocessor controlled knee-joints are powered by a battery housed inside the prosthesis.
The sensory signals are computed by the microprocessor are used to control the resistance generated by hydraulic cylinders in the knee-joint. Small valves control the amount of hydraulic fluid that can pass into and out of the cylinder, thus regulating the extension and compression of a piston connected to the upper section of the knee.
The main advantage of microprocessor controlled prosthesis is closer approximation to an amputee’s natural gait. Some even allow amputees to walk near walking speed or run. Variations in speed are also possible and are taken into account by sensors and communicated to the microprocessor, which adjusts to these changes accordingly. It also enables the amputees to walk down stairs with a step-over-step approach, rather than the one step at a time approach used with mechanical knees. However, some have some significant drawbacks that impair its use. They can be susceptible to water damage and thus great care must be taken to ensure that the prosthesis remains dry.
A myoelectric prosthesis uses electromyography signals or potentials from voluntarily contracted muscles within a person's residual limb on the surface of the skin to control the movements of the prosthesis, such as elbow flexion/extension, wrist supination/pronation (rotation) or hand opening/closing of the fingers. A prosthesis of this type utilizes the residual neuro-muscular system of the human body to control the functions of an electric powered prosthetic hand, wrist or elbow. This is as opposed to an electric switch prosthesis, which requires straps and/or cables actuated by body movements to actuate or operate switches that control the movements of a prosthesis or one that is totally mechanical. It is not clear whether those few prostheses that provide feedback signals to those muscles are also myoelectric in nature. It has a self suspending socket with pick up electrodes placed over flexors and extensors for the movement of flexion and extension respectively.
Researchers at the Rehabilitation Institute of Chicago announced in September 2013 that they have developed a robotic leg that translates neural impulses from the user's thigh muscles into movement, which is the first prosthetic leg to do so. It is currently in testing.
In order for a robotic prosthetic limb to work, it must have several components to integrate it into the body's function: Biosensors detect signals from the user's nervous or muscular systems. It then relays this information to a controller located inside the device, and processes feedback from the limb and actuator (e.g., position, force) and sends it to the controller. Examples include surface electrodes that detect electrical activity on the skin, needle electrodes implanted in muscle, or solid-state electrode arrays with nerves growing through them. One type of these biosensors are employed in myoelectric prostheses.
Mechanical sensors process aspects affecting the device (e.g., limb position, applied force, load) and relay this information to the biosensor or controller. Examples include force meters and accelerometers.
The controller is connected to the user's nerve and muscular systems and the device itself. It sends intention commands from the user to the actuators of the device, and interprets feedback from the mechanical and biosensors to the user. The controller is also responsible for the monitoring and control of the movements of the device.
An actuator mimics the actions of a muscle in producing force and movement. Examples include a motor that aids or replaces original muscle tissue.
Targeted muscle reinnervation (TMR) is a technique in which motor nerves, which previously controlled muscles on an amputated limb, are surgically rerouted such that they reinnervate a small region of a large, intact muscle, such as the pectoralis major. As a result, when a patient thinks about moving the thumb of his missing hand, a small area of muscle on his chest will contract instead. By placing sensors over the reinervated muscle, these contractions can be made to control movement of an appropriate part of the robotic prosthesis.
An emerging variant of this technique is called targeted sensory reinnervation (TSR). This procedure is similar to TMR, except that sensory nerves are surgically rerouted to skin on the chest, rather than motor nerves rerouted to muscle. The patient then feels any sensory stimulus on that area of the chest, such as pressure or temperature, as if it were occurring on the area of the amputated limb which the nerve originally innervated. In the future, artificial limbs could be built with sensors on fingertips or other important areas. When a stimulus, such as pressure or temperature, activated these sensors, an electrical signal would be sent to an actuator, which would produce a similar stimulus on the "rewired" area of chest skin. The user would then feel that stimulus as if it were occurring on an appropriate part of the artificial limb.
Recently, robotic limbs have improved in their ability to take signals from the human brain and translate those signals into motion in the artificial limb. DARPA, the Pentagon’s research division, is working to make even more advancements in this area. Their desire is to create an artificial limb that ties directly into the nervous system.
Advancements in the processors used in myoelectric arms has allowed developers to make gains in fine tuned control of the prosthetic. The Boston Digital Arm is a recent artificial limb that has taken advantage of these more advanced processors. The arm allows movement in five axes and allows the arm to be programmed for a more customized feel. Recently the i-Limb hand, invented in Edinburgh, Scotland, by David Gow has become the first commercially available hand prosthesis with five individually powered digits. The hand also possesses a manually rotatable thumb which is operated passively by the user and allows the hand to grip in precision, power and key grip modes. Raymond Edwards, Limbless Association Acting CEO, was the first amputee to be fitted with the i-LIMB by the National Health Service in the UK. The hand, manufactured by "Touch Bionics" of Scotland (a Livingston company), went on sale on 18 July 2007 in Britain. It was named alongside the Large Hadron Collider in Time magazine's top fifty innovations.
Another neural prosthetic is Johns Hopkins University Applied Physics Laboratory Proto 1. Besides the Proto 1, the university also finished the Proto 2 in 2010.
Early in 2013, Max Ortiz Catalan and Rickard Brånemark of the Chalmers University of Technology, and Sahlgrenska University Hospital in Sweden, succeeded in making the first robotic arm which is mind-controlled and can be permanently attached to the body (using osseointegration).
Robotic legs have also been developed: the Argo Medical Technologies ReWalk is an example or a recent robotic leg, targeted to replace the wheelchair. It is marketed as a "robotic pants". Walk Again project is developing a similar device.
Attachment to the body
Most prostheses can be attached to the exterior of the body, in a non-permanent way. Some others however can be attached in a permanent way. One such example are exoprostheses (see below).
Direct bone attachment / osseointegration
Osseointegration is a new method of attaching the artificial limb to the body. This method is also sometimes referred to as exoprosthesis (attaching an artificial limb to the bone), or endo-exoprosthesis.
The stump and socket method can cause significant pain in the amputee, which is why the direct bone attachment has been explored extensively. The method works by inserting a titanium bolt into the bone at the end of the stump. After several months the bone attaches itself to the titanium bolt and an abutment is attached to the titanium bolt. The abutment extends out of the stump and the (removable) artificial limb is then attached to the abutment. Some of the benefits of this method include the following:
- Better muscle control of the prosthetic.
- The ability to wear the prosthetic for an extended period of time; with the stump and socket method this is not possible.
- The ability for transfemoral amputees to drive a car.
The main disadvantage of this method is that amputees with the direct bone attachment cannot have large impacts on the limb, such as those experienced during jogging, because of the potential for the bone to break.
Cosmetic prosthesis has long been used to disguise injuries and disfigurements. With advances in modern technology, cosmesis, the creation of lifelike limbs made from silicone or PVC has been made possible. Such prosthetics, such as artificial hands, can now be made to mimic the appearance of real hands, complete with freckles, veins, hair, fingerprints and even tattoos. Custom-made cosmeses are generally more expensive (costing thousands of US dollars, depending on the level of detail), while standard cosmeses come ready-made in various sizes, although they are often not as realistic as their custom-made counterparts. Another option is the custom-made silicone cover, which can be made to match a person's skin tone but not details such as freckles or wrinkles. Cosmeses are attached to the body in any number of ways, using an adhesive, suction, form-fitting, stretchable skin, or a skin sleeve.
Unlike neuromotor prostheses, neurocognitive prostheses would sense or modulate neural function in order to physically reconstitute or augment cognitive processes such as executive function, attention, language, and memory. No neurocognitive prostheses are currently available but the development of implantable neurocognitive brain-computer interfaces has been proposed to help treat conditions such as stroke, traumatic brain injury, cerebral palsy, autism, and Alzheimer's disease. The recent field of Assistive Technology for Cognition concerns the development of technologies to augment human cognition. Scheduling devices such as Neuropage remind users with memory impairments when to perform certain activities, such as visiting the doctor. Micro-prompting devices such as PEAT, AbleLink and Guide have been used to aid users with memory and executive function problems perform activities of daily living.
In addition to the standard artificial limb for everyday use, many amputees or congenital patients have special limbs and devices to aid in the participation of sports and recreational activities.
Within science fiction, and, more recently, within the scientific community, there has been consideration given to using advanced prostheses to replace healthy body parts with artificial mechanisms and systems to improve function. The morality and desirability of such technologies are being debated by transhumanists, other ethicists, and others in general.[by whom?] Body parts such as legs, arms, hands, feet, and others can be replaced.
The first experiment with a healthy individual appears to have been that by the British scientist Kevin Warwick. In 2002, an implant was interfaced directly into Warwick's nervous system. The electrode array, which contained around a hundred electrodes, was placed in the median nerve. The signals produced were detailed enough that a robot arm was able to mimic the actions of Warwick's own arm and provide a form of touch feedback again via the implant.
- Oscar Pistorius
In early 2008, Oscar Pistorius, the "Blade Runner" of South Africa, was briefly ruled ineligible to compete in the 2008 Summer Olympics because his transtibial prosthesis limbs were said to give him an unfair advantage over runners who had ankles. One researcher found that his limbs used twenty-five percent less energy than those of an able-bodied runner moving at the same speed. This ruling was overturned on appeal, with the appellate court stating that the overall set of advantages and disadvantages of Pistorius' limbs had not been considered. Pistorius did not qualify for the South African team for the Olympics, but went on to sweep the 2008 Summer Paralympics, and has been ruled eligible to qualify for any future Olympics. He qualified for the 2011 World Championship in South Korea and reached the semifinal where he ended last timewise, he was 14th in the first round, his personal best at 400m would have given him 5th place in the finals.
At the 2012 Summer Olympics in London, Pistorius became the first amputee runner to compete at an Olympic Games. He ran in the 400 metres race semifinals;, and the 4 × 400 metres relay race finals.
In November 2012 new artificial muscles made from nanotech yarns and infused with paraffin wax were shown to lift more than 100,000 times their own weight, and generate 85 times more mechanical power than the natural muscle of the same dimensions, according to scientists. (Science Daily) (Science)
There are multiple factors to consider when designing a transtibial prosthesis. Manufacturers must make choices about their priorities regarding these factors.
Nonetheless, there are certain elements of socket and foot mechanics that are invaluable for the athlete, and these are the focus of today’s high-tech prosthetics companies:
- Fit – athletic/active amputees, or those with bony residua, may require a carefully detailed socket fit; less-active patients may be comfortable with a 'total contact' fit and gel liner
- Energy storage and return – storage of energy acquired through ground contact and utilization of that stored energy for propulsion
- Energy absorption – minimizing the effect of high impact on the musculoskeletal system
- Ground compliance – stability independent of terrain type and angle
- Rotation – ease of changing direction
- Weight – maximizing comfort, balance and speed
- Suspension – how the socket will join and fit to the limb
The buyer is also concerned with numerous other factors:
- Ease of use
- Size availability
Transradial and transtibial prostheses typically cost between US $6,000 and $8,000. Transfemoral and transhumeral prosthetics cost approximately twice as much with a range of $10,000 to $15,000 and can sometimes reach costs of $35,000. The cost of an artificial limb does recur because artificial limbs are usually replaced every 3–4 years due to wear and tear. In addition, if the socket has fit issues, the socket must be replaced within several months. If height is an issue components can be changed, such as the pylons. 
Low cost above knee prostheses often provide only basic structural support with limited function. This function is often achieved with crude, non-articulating, unstable, or manually locking knee joints. A limited number of organizations, such as the International Committee of the Red Cross (ICRC), create devices for developing countries. Their device which is manufactured by CR Equipments is a single-axis, manually operated locking polymer prosthetic knee joint.
Table. List of knee joint technologies based on the literature review. 
|Name of technology (country of origin)||Brief description||Highest level of
|ICRC knee (Switzerland)||Single-axis with manual lock||Independent field|
|ATLAS knee (UK)||Weight-activated friction||Independent field|
|POF/OTRC knee (US)||Single-axis with ext. assist||Field|
|DAV/Seattle knee (US)||Compliant polycentric||Field|
|LIMBS International M1 knee (US)||Four-bar||Field|
|LCKnee (Canada)||Single-axis with automatic lock||Field|
|None provided (Nepal)||Single-axis||Field|
|None provided (New Zealand)||Roto-molded single-axis||Field|
|None provided (India)||Six-bar with squatting||Technical development|
|Friction knee (US)||Weigh-activated friction||Technical development|
|Wedgelock knee (Australia)||Weigh-activated friction||Technical development|
|SATHI friction knee (India)||Weigh-activated friction||Limited data available|
A plan for a low-cost artificial leg, designed by Sébastien Dubois, was featured at the 2007 International Design Exhibition and award show in Copenhagen, Denmark, where it won the Index: Award. It would be able to create an energy-return prosthetic leg for US $8.00, composed primarily of fiberglass.
Prior to the 1980s, foot prostheses merely restored basic walking capabilities. These early devices can be characterized by a simple artificial attachment connecting one's residual limb to the ground.
The introduction of the Seattle Foot (Seattle Limb Systems) in 1981 revolutionized the field, bringing the concept of an Energy Storing Prosthetic Foot (ESPF) to the fore. Other companies soon followed suit, and before long, there were multiple models of energy storing prostheses on the market. Each model utilized some variation of a compressible heel. The heel is compressed during initial ground contact, storing energy which is then returned during the latter phase of ground contact to help propel the body forward.
Since then, the foot prosthetics industry has been dominated by steady, small improvements in performance, comfort, and marketability. Jaipur Foot, an artificial limb from Jaipur, India, costs about US$40.
There is currently an open Prosthetics design forum known as the "Open Prosthetics Project". The group employs collaborators and volunteers to advance Prosthetics technology while attempting to lower the costs of these necessary devices.
Another open-source prosthetics design forum is called “PATCH Project”. This forum is specially focussed on the development of prosthetics and tools for children in developing countries. The website is focussed on storing and spreading information and improving development of open-source low-cost solutions.
Low-cost prosthetics for children
In the USA an estimate was found of 32,500 children (<21 years) that suffer from major paediatric amputation, with 5,525 new cases each year, of which 3,315 congenital. Carr et al. (1998) investigated amputations caused by landmines for Afghanistan, Bosnia, Cambodia and Mozambique among children (<14 years), showing estimates of respectively 4.7, 0.19, 1.11 and 0.67 per 1000 children. Mohan (1986) indicated in India a total of 424,000 amputees (23,500 annually), of which 10.3% had an onset of disability below the age of 14, amounting to a total of about 43,700 limb deficient children in India alone.
Few low-cost solutions have been created specially for children. Underneath some of them can be found.
Pole and crutch
This hand-held pole with leather support band or platform for the limb is one of the simplest and cheapest solutions found. It serves well as a short-term solution, but is prone to rapid contracture formation if the limb is not stretched daily through a series of range-of motion (RoM) sets 
(Bamboo) PVC/plaster limbs
This also fairly simple solution comprises a plaster socket with a bamboo or PVC pipe at the bottom, optionally attached to a prosthetic foot. This solution prevents contractures because the knee is moved through its full RoM. The David Werner Collection, an online database for the assistance of disabled village children, displays manuals of production of these solutions 
Adjustable bicycle limb
This solution is built using a bicycle seat post up side down as foot, generating flexibility and (length) adjustability. It is a very cheap solution, using locally available materials.
It is an endoskeletal modular lower limb from India, which uses thermoplastic parts. Its main advantages are the small weight and adaptability.
Monolimbs are non-modular prostheses and thus require more experienced prosthetist for correct fitting, because alignment can barely be changed after production. However, their durability on average is better than low-cost modular solutions.
- πρόσθεσις. Liddell, Henry George; Scott, Robert; A Greek–English Lexicon at the Perseus Project
- "Getting an Artificial Leg Up", Australian Broadcasting Corporation, 2000. Retrieved 11 February 2007.
- Physics: A First Course. "Connections, designing a better prosthetic leg"
- "A Brief Review of the History of Amputations and Prostheses Earl E. Vanderwerker, Jr., M.D. JACPOC 1976 Vol 15, Num 5".
- "No. 1705: A 3000-Year-Old Toe". Uh.edu. 2004-08-01. Retrieved 2013-03-13.
- "Bronze single crown-like prosthetic restorations of teeth from the Late Roman period = Des restaurations par prothèses identiques à des couronnes en simple bronze de dents pendant la fin de la période romaine". Cat.inist.fr. Retrieved 2009-11-03.
- Herodotus, The Histories. 9.37
- "The Iron Hand of the Goetz von Berlichingen". Karlofgermany.com. Retrieved 2009-11-03.
- "Bryce, Geore, ''A Short History of the Canadian People''". Archive.org. Retrieved 2009-11-03.
- Romm, Sharon, "Arms by Design: From Antiquity to the Renaissance," Plastic and Reconstructive Surgery. July, 1988.
- "A Brief History of Prosthetics". inMotion: A Brief History of Prosthetics. November–December 2007. Retrieved 23 November 2010.
- Long, Ivan A. (1985). "Normal Shape-Normal Alignment (NSNA) Above-Knee Prosthesis". Clin Prosthet Orthot 9 (4): 9–14.
- Gottschalk, Frank A.; Kourosh, Sohrab; Stills, Melvin; McClellan, Bruce; Roberts, Jim (1989). "Does Socket Configuration Influence the Position of the Femur in Above-Knee Amputation?". Journal of Prosthetics & Orthotics 2 (1): 94–102. doi:10.1097/00008526-198910000-00009.
- “Blatchford Company History”, Blatchford Group.
- Pike, Alvin (May/June 1999). “The New High Tech Prostheses”. InMotion Magazine 9 (3)
- "How artificial limb is made – Background, Raw materials, The manufacturing process of artificial limb, Physical therapy, Quality control". Madehow.com. 1988-04-04. Retrieved 2010-10-03.
- Raspopovic S1, Capogrosso M, Petrini FM et al. (Jan 2014). "Restoring natural sensory feedback in real-time bidirectional hand prostheses.". Sci Transl Med. 6 (222): 222. doi:10.1126/scitranslmed.3006820. PMID 24500407.
- "With a new prosthetic, researchers have managed to restore the sense of touch for a Denmark man who lost his left hand nine years ago.", USA Today, 4:54 p.m. EST February 5, 2014
- "Artificial hand offering immediate touch response a success", Channelnewsasia, Feb 07, 2014
- Smit G, Plettenburg DH (2010). "Efficiency of Voluntary Closing Hand and Hook Prostheses". Prosthetics and Orthotics International 34 (4): 411–427. doi:10.3109/03093646.2010.486390. PMID 20849359. Retrieved 2011-03-11.
- Smit, G; Bongers, RM; Van der Sluis, CK; Plettenburg, DH (2012). "Efficiency of voluntary opening hand and hook prosthetic devices: 24 years of development?". Journal of Rehabilitation Research and Development 49 (4): 523–534. doi:10.1682/JRRD.2011.07.0125. PMID 22773256.
- Ephraim, P.L. and Dillingham, T.R. and Sector, M. and Pezzin L.E. and MacKenzie, E.J. (2003) Epidemiology of Limb Loss and Congenital Limb Deficiency: A Review of the Literature.
- Mak, A.F.T. and Zhang, M. and Boone, D.A. (2001) State-of-the-art research in lower-limb prosthetic biomechanicssocket interface: A review.
- Strait, E. (2006) Prosthetics in Developing Countries.
- Stark, G. (2005) Perspectives on how and why feet are prescribed.
- Jian, Y. and Winter, D.A. and Ishac, M.G. and Gilchrist, L. (1993) Trajectory of the body COG and COP during initiation and termination of gait.
- ANDRYSEK, J., "Lower-limb prosthetic technologies in the developing world: A review of literature from 1994–2010" Prosthetics and Orthotics International, 2010; Early Online, 1–21.
- "Retrieved 14 April 2009". Freedom-innovations.com. Retrieved 2010-10-03.
- “The SLK, The Self-Learning Knee”, DAW Industries. Retrieved 16 March 2008.
- Marriott, Michel (2005-06-20). "Titanium and Sensors Replace Ahab's Peg Leg". The New York Times. Retrieved 2008-10-30.
- Martin, Craig W. (November 2003) “Otto Bock C-leg: A review of its effectiveness”. WCB Evidence Based Group
- Sherman, E. David (1964). "A Russian Bioelectric-Controlled Prosthesis: Report of a Research Team from the Rehabilitation Institute of Montreal". Canadian Medical Association Journal 91 (24): 1268–1270. PMC 1927453. PMID 14226106.
- Muzumdar, Ashok (2004). Powered Upper Limb Prostheses: Control, Implementation and Clinical Application. Springer. ISBN 978-3-540-40406-4.
- Rehabilitation Institute of Chicago First to Develop Thought Controlled Robotic Leg
- Kuiken TA, Miller LA, Lipschutz RD, Lock BA, Stubblefield K, Marasco PD, Zhou P, Dumanian GA (February 3, 2007). "Targeted reinnervation for enhanced prosthetic arm function in a woman with a proximal amputation: a case study". Lancet 369 (9559): 371–80. doi:10.1016/S0140-6736(07)60193-7. PMID 17276777.
- "Blogs: TR Editors' blog: Patients Test an Advanced Prosthetic Arm". Technology Review. 2009-02-10. Retrieved 2010-10-03.
- "Defense Sciences Office". Darpa.mil. Retrieved 2010-10-03.
- "Advanced Signal Processing Dramatically Improves Capability of Artificial Limbs"[dead link], SIGMO Technology, 2005. Retrieved 11 February 2007.
- Fildes, Jonathan (9 June 2008). "Bionic hand wins top tech prize". BBC News. Retrieved 25 April 2010.
- "Touch Bionics". Touch Bionics. Retrieved 2010-10-03.
- Highfield, Roger (31 May 2008). "Gripping stuff". The Daily Telegraph (London). Retrieved 25 April 2010.
- "Bionic hand makes top inventions list // Current". Current.com. 2008-11-06. Retrieved 2010-10-03.
- "Proto 1 and Proto 2". Ric.org. 2007-05-01. Retrieved 2010-10-03.
- World Premiere of Muscle and Nerve Controlled Arm Prosthesis
- Permanently attached robotic arm, operated on mind-control
- Max Ortiz Catalan and his robotic arm
- ReWalk robotic pants
- Walk Again Project robotic legs
- Serruya MD, Kahana MJ (2008). "Techniques and devices to restore cognition". Behav Brain Res 192 (2): 149–65. doi:10.1016/j.bbr.2008.04.007. PMC 3051349. PMID 18539345.
- Enhancements, Oxford Uehiro Centre for Practical Ethics
- Caplan A., Elliott C. Is It Ethical to Use Enhancement Technologies to Make Us Better than Well?
- Allen E. Buchanan, Beyond Humanity?: The Ethics of Biomedical Enhancement, Oxford Scholarship Online
- Allen E. Buchanan, Beyond Humanity? The Ethics of Biomedical Enhancement
- Warwick,K, Gasson,M, Hutt,B, Goodhew,I, Kyberd,P, Andrews,B, Teddy,P and Shad,A. “The Application of Implant Technology for Cybernetic Systems”, Archives of Neurology, 60(10), pp1369-1373, 2003
- "IEEE Spectrum: Dean Kamen's "Luke Arm" Prosthesis Readies for Clinical Trials".
- Robert Klemko (10 August 2012), "Oscar Pistorius makes history, leaves without medal", USA Today, archived from the original on 11 August 2012
- Oscar Pistorius makes Olympic history in 400m at London 2012, BBC Sport, 4 August 2012
- Bill Chappell (4 August 2012), Oscar Pistorius makes Olympic history in 400 meters, and moves on to semifinal, NPR, archived from the original on 4 August 2012
- Men's 400m – semifinals, retrieved 4 August 2012
- Greenberg, Chris (10 August 2012), Oscar Pistorius, South African 4×400m relay team finish 8th as Bahamas wins gold, Huffington Post, archived from the original on 11 August 2012
- Hawking, Pistorius open London's Paralympics: Wheelchair-bound physicist Stephen Hawking challenged athletes to 'look to the stars' as he helped open a record-setting Paralympics Games that will run for 11 days in near sold-out venues, Yahoo! Sports, 30 August 2012, archived from the original on 30 August 2012
- "Cost of Prosthetics Stirs Debate", Boston Globe, 5 July 2005. Retrieved 11 February 2007.
- "ICRC: Trans-Femoral Prosthesis – Manufacturing Guidelines" (PDF). Retrieved 2010-10-03.
- ANDRYSEK, J., "Lower-limb prosthetic technologies in the developing world: A review of literature from 1994–2010" Prosthetics and Orthotics International, 2010; Early Online, 1–21.
- INDEX:2007 INDEX: AWARD[dead link]
- Open Prosthetics Website
- PATCH Project website
- Krebs, D.E. and Edelstein, J.E. and Thornby, M.A. (1991) Prosthetic Management of Children with Limb Deficiencies.
- Carr, D.B. (1998) Pain and Rehabilitation from Landmine Injury
- Mohan, D. (1986) A Report on Amputees in India.
- Strait, E. Prosthetics in Deceloping Countries
- David Werner Collection: http://www.dinf.ne.jp/doc/english/global/david/dwe002/dwe00201.html
- Cheng, V. (2004) A victim assistance solution. http://www.ispo.ca/files/bicycle-prosthesis.pdf
|Wikimedia Commons has media related to Prosthetics.|
- Murdoch, George; A. Bennett Wilson, Jr. (1997). A Primer on Amputations and Artificial Limbs. United States of America: Charles C Thomas Publisher, Ltd. pp. 3–31. ISBN 0-398-06801-1.
- ‘Biomechanics of running: from faulty movement patterns come injury.' Sports Injury Bulletin.
- Edelstein, J. E. Prosthetic feet. State of the Art. Physical Therapy 68(12) Dec 1988: 1874–1881.
- Gailey, Robert. The Biomechanics of Amputee Running. October 2002.
- Hafner, B. J., Sanders, J. E., Czerniecki, J. M., Ferguson, J. Transtibial energy-storage-and-return prosthetic devices: A review of energy concepts and a proposed nomenclature. Journal of Rehabilitation Research and Development Vol. 39, No. 1 Jan/Feb 2002: 1–11.
- Video on YouTube