Protein-synthesizing GTPase

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Protein-synthesizing GTPase
Identifiers
EC number 3.6.5.3
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Protein-synthesizing GTPases (EC 3.6.5.3, elongation factor (EF), initiation factor (IF), peptide-release or termination factor) are enzymes involved in mRNA translation into protein by the ribosome, with system name GTP phosphohydrolase (mRNA-translation-assisting).[1][2][3][4][5] They usually include translation initiation factors such as IF-2 and translation elongation factors such as EF-Tu.

References[edit]

  1. ^ Kurzchalia, T.V., Bommer, U.A., Babkina, G.T. and Karpova, G.G. (1984). "GTP interacts with the γ-subunit of eukaryotic initiation factor EIF-2". FEBS Lett. 175 (2): 313–316. doi:10.1016/0014-5793(84)80758-9. PMID 6566615. 
  2. ^ Kisselev, L.L. and Frolova, L.Yu. (1995). "Termination of translation in eukaryotes". Biochem. Cell Biol. 73 (11-12): 1079–1086. doi:10.1139/o95-116. PMID 8722024. 
  3. ^ Rodnina, M.V., Savelsberg, A., Katunin, V.I. and Wintermeyer, W. (1997). "Hydrolysis of GTP by elongation factor G drives tRNA movement on the ribosome". Nature 385 (6611): 37–41. doi:10.1038/385037a0. PMID 8985244. 
  4. ^ Freistroffer, D.V., Pavlov, M.Y., MacDougall, J., Buckingham, R.H. and Ehrenberg, M. (1997). "Release factor RF3 in E. coli accelerates the dissociation of release factors RF1 and RF2 from the ribosome in a GTP-dependent manner". EMBO J. 16: 4126–4133. doi:10.1093/emboj/16.13.4126. PMID 9233821. 
  5. ^ Krab, I.M. and Parmeggiani, A. (1998). "EF-Tu, a GTPase odyssey". Biochim. Biophys. Acta 1443 (1-2): 1–22. doi:10.1016/s0167-4781(98)00169-9. PMID 9838020. 

External links[edit]