Protein C inhibitor

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Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
Protein SERPINA5 PDB 1lq8.png
PDB rendering based on 1lq8.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols SERPINA5 ; PAI-3; PAI3; PCI; PCI-B; PLANH3; PROCI
External IDs OMIM601841 MGI107817 HomoloGene20159 GeneCards: SERPINA5 Gene
RNA expression pattern
PBB GE SERPINA5 209443 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5104 268591
Ensembl ENSG00000188488 ENSMUSG00000041550
UniProt P05154 P70458
RefSeq (mRNA) NM_000624 NM_172953
RefSeq (protein) NP_000615 NP_766541
Location (UCSC) Chr 14:
95.03 – 95.06 Mb
Chr 12:
104.1 – 104.11 Mb
PubMed search [1] [2]

Protein C inhibitor (PCI, SERPINA5) is a serine protease inhibitor (serpin) which limits the expression of protein C (an anticoagulant).

An N-terminal fragment of PCI is a possible serum biomarker for prostate cancer.[1]

Protein C inhibitor is activated by heparin against thrombin.[2]

Interactions[edit]

Protein C inhibitor has been shown to interact with Prostate specific antigen,[3][4] Protein C[5][6] and PLAU.[5][7]

See also[edit]

Further reading[edit]

References[edit]

  1. ^ "Predicting Prostate Cancer Biochemical Recurrence Using a Panel of Serum Proteomic Biomarkers". 
  2. ^ Huntington, JA (Jun 2013). "Thrombin inhibition by the serpins.". Journal of thrombosis and haemostasis : JTH. 11 Suppl 1: 254–64. doi:10.1111/jth.12252. PMID 23809129. 
  3. ^ Christensson, A; Lilja H (February 1994). "Complex formation between protein C inhibitor and prostate-specific antigen in vitro and in human semen". Eur. J. Biochem. (GERMANY) 220 (1): 45–53. doi:10.1111/j.1432-1033.1994.tb18597.x. ISSN 0014-2956. PMID 7509746. 
  4. ^ Kise, H; Nishioka J, Kawamura J, Suzuki K (May 1996). "Characterization of semenogelin II and its molecular interaction with prostate-specific antigen and protein C inhibitor". Eur. J. Biochem. (GERMANY) 238 (1): 88–96. doi:10.1111/j.1432-1033.1996.0088q.x. ISSN 0014-2956. PMID 8665956. 
  5. ^ a b España, F; Berrettini M, Griffin J H (August 1989). "Purification and characterization of plasma protein C inhibitor". Thromb. Res. (UNITED STATES) 55 (3): 369–84. doi:10.1016/0049-3848(89)90069-8. ISSN 0049-3848. PMID 2551064. 
  6. ^ Strandberg, K; Kjellberg M, Erb E M, Persson U, Mosher D F, Villoutreix B O, Stenflo J (December 2000). "Activated protein C-protein C inhibitor complex formation: characterization of a neoepitope provides evidence for extensive insertion of the reactive center loop". Biochemistry (UNITED STATES) 39 (51): 15713–20. doi:10.1021/bi001640h. ISSN 0006-2960. PMID 11123896. 
  7. ^ Geiger, M; Huber K, Wojta J, Stingl L, Espana F, Griffin J H, Binder B R (August 1989). "Complex formation between urokinase and plasma protein C inhibitor in vitro and in vivo". Blood (UNITED STATES) 74 (2): 722–8. ISSN 0006-4971. PMID 2752144. 

External links[edit]