Protein C inhibitor

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Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
Protein SERPINA5 PDB 1lq8.png
PDB rendering based on 1lq8.
Available structures
PDB Ortholog search: PDBe, RCSB
External IDs OMIM601841 MGI107817 HomoloGene20159 GeneCards: SERPINA5 Gene
RNA expression pattern
PBB GE SERPINA5 209443 at tn.png
More reference expression data
Species Human Mouse
Entrez 5104 268591
Ensembl ENSG00000188488 ENSMUSG00000041550
UniProt P05154 P70458
RefSeq (mRNA) NM_000624 NM_172953
RefSeq (protein) NP_000615 NP_766541
Location (UCSC) Chr 14:
95.03 – 95.06 Mb
Chr 12:
104.1 – 104.11 Mb
PubMed search [1] [2]

Protein C inhibitor (PCI, SERPINA5) is a serine protease inhibitor (serpin) which limits the expression of protein C (an anticoagulant).

An N-terminal fragment of PCI is a possible serum biomarker for prostate cancer.[1]

Protein C inhibitor is activated by heparin against thrombin.[2]


Protein C inhibitor has been shown to interact with Prostate specific antigen,[3][4] Protein C[5][6] and PLAU.[5][7]

See also[edit]

Further reading[edit]


  1. ^ "Predicting Prostate Cancer Biochemical Recurrence Using a Panel of Serum Proteomic Biomarkers". 
  2. ^ Huntington, JA (Jun 2013). "Thrombin inhibition by the serpins.". Journal of thrombosis and haemostasis : JTH. 11 Suppl 1: 254–64. doi:10.1111/jth.12252. PMID 23809129. 
  3. ^ Christensson, A; Lilja H (February 1994). "Complex formation between protein C inhibitor and prostate-specific antigen in vitro and in human semen". Eur. J. Biochem. (GERMANY) 220 (1): 45–53. doi:10.1111/j.1432-1033.1994.tb18597.x. ISSN 0014-2956. PMID 7509746. 
  4. ^ Kise, H; Nishioka J; Kawamura J; Suzuki K (May 1996). "Characterization of semenogelin II and its molecular interaction with prostate-specific antigen and protein C inhibitor". Eur. J. Biochem. (GERMANY) 238 (1): 88–96. doi:10.1111/j.1432-1033.1996.0088q.x. ISSN 0014-2956. PMID 8665956. 
  5. ^ a b España, F; Berrettini M; Griffin J H (August 1989). "Purification and characterization of plasma protein C inhibitor". Thromb. Res. (UNITED STATES) 55 (3): 369–84. doi:10.1016/0049-3848(89)90069-8. ISSN 0049-3848. PMID 2551064. 
  6. ^ Strandberg, K; Kjellberg M; Erb E M; Persson U; Mosher D F; Villoutreix B O; Stenflo J (December 2000). "Activated protein C-protein C inhibitor complex formation: characterization of a neoepitope provides evidence for extensive insertion of the reactive center loop". Biochemistry (UNITED STATES) 39 (51): 15713–20. doi:10.1021/bi001640h. ISSN 0006-2960. PMID 11123896. 
  7. ^ Geiger, M; Huber K; Wojta J; Stingl L; Espana F; Griffin J H; Binder B R (August 1989). "Complex formation between urokinase and plasma protein C inhibitor in vitro and in vivo". Blood (UNITED STATES) 74 (2): 722–8. ISSN 0006-4971. PMID 2752144. 

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