Protein SET

From Wikipedia, the free encyclopedia
Jump to: navigation, search
SET nuclear proto-oncogene
Protein SET PDB 2e50.png
PDB rendering based on 2e50.
Available structures
PDB Ortholog search: PDBe, RCSB
External IDs OMIM600960 MGI1860267 HomoloGene55707 GeneCards: SET Gene
Species Human Mouse
Entrez 6418 56086
Ensembl ENSG00000119335 ENSMUSG00000054766
UniProt Q01105 Q9EQU5
RefSeq (mRNA) NM_001122821 NM_001204875
RefSeq (protein) NP_001116293 NP_001191804
Location (UCSC) Chr 9:
131.45 – 131.46 Mb
Chr 2:
30.06 – 30.07 Mb
PubMed search [1] [2]

Protein SET is a protein that in humans is encoded by the SET gene.[1][2][3]


Protein SET has been shown to interact with TAF1A,[4] NME1,[5] CDK5R1,[6] Acidic leucine-rich nuclear phosphoprotein 32 family member A[4][7] and KLF5.[8]


  1. ^ von Lindern M, van Baal S, Wiegant J, Raap A, Hagemeijer A, Grosveld G (Aug 1992). "Can, a putative oncogene associated with myeloid leukemogenesis, may be activated by fusion of its 3' half to different genes: characterization of the set gene". Mol Cell Biol 12 (8): 3346–55. PMC 364582. PMID 1630450. 
  2. ^ Li M, Makkinje A, Damuni Z (Jun 1996). "The myeloid leukemia-associated protein SET is a potent inhibitor of protein phosphatase 2A". J Biol Chem 271 (19): 11059–62. doi:10.1074/jbc.271.19.11059. PMID 8626647. 
  3. ^ "Entrez Gene: SET SET translocation (myeloid leukemia-associated)". 
  4. ^ a b Seo, S B; McNamara P; Heo S; Turner A; Lane W S; Chakravarti D (Jan 2001). "Regulation of histone acetylation and transcription by INHAT, a human cellular complex containing the set oncoprotein". Cell (United States) 104 (1): 119–30. doi:10.1016/S0092-8674(01)00196-9. ISSN 0092-8674. PMID 11163245. 
  5. ^ Fan, Zusen; Beresford Paul J; Oh David Y; Zhang Dong; Lieberman Judy (Mar 2003). "Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL-mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor". Cell (United States) 112 (5): 659–72. doi:10.1016/S0092-8674(03)00150-8. ISSN 0092-8674. PMID 12628186. 
  6. ^ Qu, Dianbo; Li Qing; Lim Hui-Ying; Cheung Nam Sang; Li Rong; Wang Jerry H; Qi Robert Z (Mar 2002). "The protein SET binds the neuronal Cdk5 activator p35nck5a and modulates Cdk5/p35nck5a activity". J. Biol. Chem. (United States) 277 (9): 7324–32. doi:10.1074/jbc.M107270200. ISSN 0021-9258. PMID 11741927. 
  7. ^ Fan, Zusen; Beresford Paul J; Zhang Dong; Lieberman Judy (Apr 2002). "HMG2 Interacts with the Nucleosome Assembly Protein SET and Is a Target of the Cytotoxic T-Lymphocyte Protease Granzyme A". Mol. Cell. Biol. (United States) 22 (8): 2810–20. doi:10.1128/MCB.22.8.2810-2820.2002. ISSN 0270-7306. PMC 133744. PMID 11909973. 
  8. ^ Miyamoto, Saku; Suzuki Toru, Muto Shinsuke, Aizawa Kenichi, Kimura Akatsuki, Mizuno Yoshiko, Nagino Tomoko, Imai Yasushi, Adachi Naruhiko, Horikoshi Masami, Nagai Ryozo (Dec 2003). "Positive and Negative Regulation of the Cardiovascular Transcription Factor KLF5 by p300 and the Oncogenic Regulator SET through Interaction and Acetylation on the DNA-Binding Domain". Mol. Cell. Biol. (United States) 23 (23): 8528–41. doi:10.1128/MCB.23.23.8528-8541.2003. ISSN 0270-7306. PMC 262669. PMID 14612398. 

Further reading[edit]