Proteinase 3

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Proteinase 3
PBB Protein PRTN3 image.jpg
PDB rendering based on 1fuj.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols PRTN3 ; ACPA; AGP7; C-ANCA; CANCA; MBN; MBT; NP-4; NP4; P29; PR-3; PR3
External IDs OMIM177020 MGI893580 HomoloGene120934 ChEMBL: 3900 GeneCards: PRTN3 Gene
EC number 3.4.21.76
RNA expression pattern
PBB GE PRTN3 207341 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5657 19152
Ensembl ENSG00000196415 ENSMUSG00000057729
UniProt P24158 Q61096
RefSeq (mRNA) NM_002777 NM_011178
RefSeq (protein) NP_002768 NP_035308
Location (UCSC) Chr 19:
0.84 – 0.85 Mb
Chr 10:
79.87 – 79.88 Mb
PubMed search [1] [2]

Proteinase 3 also known as PRTN3 is an enzyme that in humans is encoded by the PRTN3 gene.[1]

Function[edit]

PRTN3 is a serine protease enzyme expressed mainly in neutrophil granulocytes. Its exact role in the function of the neutrophil is unknown, but, in human neutrophils, proteinase 3 contributes to the proteolytic generation of antimicrobial peptides. It is also the epitope of anti-neutrophil cytoplasmic antibodies (ANCAs) of the c-ANCA (cytoplasmic subtype) class, a type of antibody frequently found in the disease granulomatosis with polyangiitis (formerly known as "Wegener's granulomatosis").[2]

References[edit]

  1. ^ Campanelli D, Melchior M, Fu Y, Nakata M, Shuman H, Nathan C, Gabay JE (December 1990). "Cloning of cDNA for proteinase 3: a serine protease, antibiotic, and autoantigen from human neutrophils". J. Exp. Med. 172 (6): 1709–15. doi:10.1084/jem.172.6.1709. PMC 2188764. PMID 2258701. 
  2. ^ van der Geld YM, Limburg PC, Kallenberg CG (February 2001). "Proteinase 3, Wegener's autoantigen: from gene to antigen". J. Leukoc. Biol. 69 (2): 177–90. PMID 11272267. 

Further reading[edit]

External links[edit]