Proteostasis, a portmanteau of the words protein and homeostasis, is the concept that there are competing and integrated biological pathways within cells that control the biogenesis, folding, trafficking and degradation of proteins present within and outside the cell. The concept of proteostasis maintenance is central to understanding the cause of diseases associated with excessive protein misfolding and degradation leading to loss-of-function phenotypes, as well as aggregation-associated degenerative disorders. Therefore, adapting proteostasis should enable the restoration of proteostasis, once its loss leads to pathology.
Cellular proteostasis is key to ensuring successful development, healthy aging, resistance to environmental stresses, and to minimize homeostasis perturbations by pathogens such as viruses. Proteostasis in distinct subcellular environments is constantly monitored by stress-responsive signaling pathways unique to those compartments, which match proteostasis capacity to demand employing a transcriptional program and translational attenuation. Transcriptional up- and down-regulation enhances folding and degradation capacity in unison, which is probably critical for maintaining constant protein concentrations required for normal cellular physiology. As such, maintenance of proteostasis prevents disease onset.
The proteostasis network refers to the 2000+ genes in mammals encoding proteins that work together as a system to control protein concentration, conformation through interactions of the proteome with chaperone systems and folding enzymes, protein degradation mediated by the ubiquitin proteasome system and the lysosome, subcellular location, and other attributes of the proteome.
Numerous academic  and a few commercial organizations are currently exploring the hypothesis that the proteostasis network can be adapted with small molecules or using biological strategies to alleviate loss-of-function diseases (e.g. lysosomal storage diseases or cystic fibrosis) and gain-of-toxic function maladies where the aggregation of proteins leads to post-mitotic tissue degeneration (e.g. Alzheimer's disease) 
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- Proteostasis: where do you work on the network? - Introduction to Proteostasis by Enzo Life Sciences
- Proteostasis Therapeutics Biotechnology company developing proteostasis regulators