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Protium may refer to:
- In physics and chemistry, protium refers to hydrogen-1, the most common isotope of the element hydrogen, with one proton and no neutrons. It is the most stable isotopic form of hydrogen. At normal condition it exists about 99.985% in nature.
- Protium (plant) refers to a genus of chiefly tropical American trees in the family Burseraceae, having fragrant wood
- Protium (computer language) is a universal, symbolic programming language system
- In medicine, Protium is a commercial name for pantoprazole, a so-called "proton inhibitor" drug
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