Psammoma bodies are associated with the papillary (nipple-like) histomorphology and are thought to arise from (1) the infarction and calcification of papillae tips and (2) calcification of intralymphatic tumor thrombi.
Association with lesions
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Psammoma bodies are commonly seen in certain tumors such as:
- Papillary thyroid carcinoma
- Papillary renal cell carcinoma
- Ovarian papillary serous cystadenoma and cystadenocarcinoma
- Endometrial adenocarcinomas (Papillary serous carcinoma ~3%-4%)
- Meningiomas, in the central nervous system
- Peritoneal and Pleural Mesothelioma
- Somatostatinoma (pancreas)
- Prolactinoma of the pituitary 
- Mesothelioma, in membranes that line body cavities
Psammoma bodies may be seen in:
Psammoma bodies usually have a laminar appearance, are circular, acellular and basophilic.
- Johannessen JV, Sobrinho-Simões M (September 1980). "The origin and significance of thyroid psammoma bodies". Lab. Invest. 43 (3): 287–96. PMID 7401638.
- Ovarian papillary serous cystadenocarcinoma at WebPath, The Internet Pathology Laboratory for Medical Education at Mercer University School of Medicine. Retrieved July 2011
- 10.1148/rg.306105523, October 2010, RadioGraphics, 30, 1445-1464
- Robbin's Pathology, Eight Ed
- Hallman KB, Nahhas WA, Connelly PJ (September 1991). "Endosalpingiosis as a source of psammoma bodies in a Papanicolaou smear. A case report". J Reprod Med 36 (9): 675–8. PMID 1774734.
- Rapini, Ronald. Practical Dermatopathology. Elsevier Mosby, 2005, p. 10.
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