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Pseudohyperaldosteronism (also pseudoaldosteronism) is a medical condition that mimics hyperaldosteronism. Like hyperaldosteronism, it produces hypertension associated with low plasma renin activity, and metabolic alkalosis associated with hypokalemia. Unlike hyperaldosteronism, it involves aldosterone levels that are normal or low (hypoaldosteronism).
This condition has several known causes, dietary and genetic. Dietary causes include the chronic excessive ingestion of licorice. Licorice inhibits the 11-beta hydroxysteroid dehydrogenase type II (Protein:HSD11B2) enzyme resulting in inappropriate stimulation of the mineralocorticoid receptor by cortisol.
- Armanini D, Calò L, Semplicini A (June 2003). "Pseudohyperaldosteronism: pathogenetic mechanisms". Crit Rev Clin Lab Sci 40 (3): 295–335. doi:10.1080/713609355. PMID 12892318.
- Sigurjonsdottir HA, Axelson M, Johannsson G, Manhem K, Nyström E, Wallerstedt S (2006). "The liquorice effect on the RAAS differs between the genders". Blood Press. 15 (3): 169–72. doi:10.1080/08037050600593060. PMID 16864159.
- Takeuchi K, Abe K, Sato M, et al. (February 1989). "Plasma aldosterone level in a female case of pseudohyperaldosteronism (Liddle's syndrome)". Endocrinol. Jpn. 36 (1): 167–73. doi:10.1507/endocrj1954.36.167. PMID 2659310.
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