A psychoactive drug, psychopharmaceutical, or psychotropic is a chemical substance that crosses the blood–brain barrier and acts primarily upon the central nervous system where it affects brain function, resulting in alterations in perception, mood, consciousness, cognition, and behavior. These substances may be used recreationally, to purposefully alter one's consciousness, or as entheogens, for ritual, spiritual, or shamanic purposes, as a tool for studying or augmenting the mind. Some categories of psychoactive drugs, which are prescription medicines, have medical therapeutic utility, such as anesthetics, analgesics, hormonal preparations, anticonvulsant and antiparkinsonian drugs or for the treatment of neuro-psychiatric disorders, as hypnotic drugs, anxiolytic and some stimulant medications used in ADHD and some sleep disorders. There are also some psychoactive substances used in the detoxification and rehabilitation programs for psychoactive drug users.
Psychoactive substances often bring about subjective (although these may be objectively observed) changes in consciousness and mood that the user may find pleasant (e.g. euphoria) or advantageous (e.g. increased alertness) and are thus reinforcing. Thus, many psychoactive substances are abused, that is, used excessively, despite health risks or negative consequences. With sustained use of some substances, psychological and physical dependence ("addiction") may develop, making the cycle of abuse even more difficult to interrupt. Drug rehabilitation aims to break this cycle of dependency, through a combination of psychotherapy, support groups, maintenance and even other psychoactive substances. However, the reverse is also true in some cases, that certain experiences on drugs may be so unfriendly and uncomforting that the user may never want to try the substance again. This is especially true of the deliriants (e.g. Jimson weed) and powerful dissociatives (e.g. Salvia divinorum). Most purely psychedelic drugs are considered to be non-addictive (e.g. LSD, psilocybin, mescaline). "Psychedelic amphetamines" or empathogen-entactogens (such as MDA and MDMA) may produce an additional stimulant or euphoriant effect, and thus have an addiction potential.
In part because of this potential for abuse and dependency, the ethics of drug use are debated. Many governments worldwide place restrictions on drug production and sales in an attempt to decrease drug abuse. Ethical concerns have also been raised about over-use of these drugs clinically, and about their marketing by manufacturers.
- 1 History
- 2 Uses
- 3 Administration
- 4 Effects
- 5 Addiction
- 6 Legality
- 7 See also
- 8 References
- 9 External links
Psychoactive drug use can be traced to prehistoric times. There is archaeological evidence of the use of psychoactive substances (mostly plants) dating back at least 10,000 years, and historical evidence of cultural use over the past 5,000 years. The chewing of coca leaves, for example, dates back over 8000 years ago in Peruvian society.
Medicinal use is one important facet of psychoactive drug usage. However, some have postulated that the urge to alter one's consciousness is as primary as the drive to satiate thirst, hunger or sexual desire. Supporters of this belief contend that the history of drug use and even children's desire for spinning, swinging, or sliding indicate that the drive to alter one's state of mind is universal.
One of the first people to articulate this point of view, set aside from a medicinal context, was American author Fitz Hugh Ludlow (1836–1870) in his book The Hasheesh Eater (1857): "...drugs are able to bring humans into the neighborhood of divine experience and can thus carry us up from our personal fate and the everyday circumstances of our life into a higher form of reality. It is, however, necessary to understand precisely what is meant by the use of drugs. We do not mean the purely physical craving...That of which we speak is something much higher, namely the knowledge of the possibility of the soul to enter into a lighter being, and to catch a glimpse of deeper insights and more magnificent visions of the beauty, truth, and the divine than we are normally able to spy through the cracks in our prison cell. But there are not many drugs which have the power of stilling such craving. The entire catalog, at least to the extent that research has thus far written it, may include only opium, hashish, and in rarer cases alcohol, which has enlightening effects only upon very particular characters."
This relationship is not limited to humans. A number of animals consume different psychoactive plants, animals, berries and even fermented fruit, becoming intoxicated, such as cats after consuming catnip. Traditional legends of sacred plants often contain references to animals that introduced humankind to their use. Animals and psychoactive plants appear to have co-evolved, possibly explaining why these chemicals and their receptors exist within the nervous system.
During the 20th century, many governments across the world initially responded to the use of recreational drugs by banning them and making their use, supply, or trade a criminal offense. A notable example of this is the Prohibition era in the United States, where alcohol was made illegal for 13 years. However, many governments, government officials and persons in law enforcement have concluded that illicit drug use cannot be sufficiently stopped through criminalization. Organizations such as Law Enforcement Against Prohibition (LEAP) have come to such a conclusion believing "the existing drug policies have failed in their intended goals of addressing the problems of crime, drug abuse, addiction, juvenile drug use, stopping the flow of illegal drugs into this country and the internal sale and use of illegal drugs. By fighting a war on drugs the government has increased the problems of society and made them far worse. A system of regulation rather than prohibition is a less harmful, more ethical and a more effective public policy."[not in citation given] In some countries, there has been a move toward harm reduction by health services, where the use of illicit drugs is neither condoned nor promoted, but services and support are provided to ensure users have adequate factual information readily available, and that the negative effects of their use be minimized. Such is the case of Portuguese drug policy of decriminalization, which achieved its primary goal of reducing the adverse health effects of drug abuse.
Psychoactive substances are used by humans for a number of different purposes to achieve a specific end. These uses vary widely between cultures. Some substances may have controlled or illegal uses while others may have shamanic purposes, and still others are used medicinally. Other examples would be social drinking or sleep aids. Caffeine is the world's most widely consumed psychoactive substance, but unlike many others, it is legal and unregulated in nearly all jurisdictions. In North America, 90% of adults consume caffeine daily.
Psychoactive drugs are divided into different groups according to their pharmacological effects. Commonly used psychoactive drugs and groups:
- Example: Benzodiazepine
- Stimulants ("uppers"). This category comprises substances that wake one up, stimulate the mind, and may even cause euphoria, but do not affect perception.
- Depressants ("downers"), including sedatives, hypnotics, and narcotics. This category includes all of the calmative, sleep-inducing, anxiety-reducing, anesthetizing substances, which sometimes induce perceptual changes, such as dream images, and also often evoke feelings of euphoria.
- Hallucinogens, including psychedelics, dissociatives and deliriants. This category encompasses all those substances that produce distinct alterations in perception, sensation of space and time, and emotional states 
Use in practice: The theory of dose, set, and setting
The theory of dosage, set, and setting is a useful model in dealing with the effects of psychoactive substances, especially in a controlled therapeutic setting as well as in recreational use. Dr. Timothy Leary, based on his own experiences and systematic observations on psychedelics, developed this theory along with his colleagues Ralph Metzner, and Richard Alpert (Ram Dass) in the 1960s.
The second factor, dosage, has been a truism since ancient times, or at least since Paracelsus who said, "Dose makes the poison." Some compounds are beneficial or pleasurable when consumed in small amounts, but harmful, deadly, or evoke discomfort in higher doses.
The set is the internal attitudes and constitution of the person, including their expectations, wishes, and fears. This factor is especially important for the hallucinogens, which have the ability to make conscious experiences out of the unconscious. In traditional cultures, set is shaped primarily by the worldview that all the members of the culture share.
The third aspect is setting, which pertains to the surroundings, the place, and the time in which the experiences transpire.
This theory clearly states that the effects are equally the result of chemical, pharmacological, psychological, and physical influences. The model that Timothy Leary proposed applied to the psychedelics, although it also applies to other psychoactives.
General anesthetics are a class of psychoactive drug used on patients to block pain and other sensations. Most anesthetics induce unconsciousness, which allows patients to undergo medical procedures like surgery without physical pain or emotional trauma. To induce unconsciousness, anesthetics affect the GABA and NMDA systems. For example, halothane is a GABA agonist, and ketamine is an NMDA receptor antagonist.
Psychoactive drugs are often prescribed to manage pain. The subjective experience of pain is primarily regulated by endogenous opioid peptides. Thus, pain can often be managed using psychoactives that operate on this neurotransmitter system, also known as opioid receptor agonists. This class of drugs can be highly addictive, and includes opiate narcotics, like morphine and codeine. NSAIDs, such as aspirin and ibuprofen, are also analgesics. These agents also reduce eicosanoid-mediated inflammation by inhibiting the enzyme cyclooxygenase.
Psychiatric medications are psychoactive drugs prescribed for the management of mental and emotional disorders. There are six major classes of psychiatric medications:
- Antidepressants, treat disparate disorders such as clinical depression, dysthymia, anxiety, eating disorders and borderline personality disorder.
- Stimulants, which are used to treat disorders such as attention deficit disorder and narcolepsy and to suppress the appetite.
- Antipsychotics, which are used to treat psychotic symptoms, such as those associated with schizophrenia or severe mania.
- Mood stabilizers, which are used to treat bipolar disorder and schizoaffective disorder.
- Anxiolytics, which are used to treat anxiety disorders.
- Depressants, which are used as hypnotics, sedatives, and anesthetics, depending upon dosage.
In addition, several psychoactive substances are currently employed to treat dependence on other substances. These include acamprosate or naltrexone in the treatment of alcoholism, or methadone or buprenorphine maintenance therapy in the case of opioid dependency.
Exposure to psychoactive drugs can cause changes to the brain that counteract their effects, which may lead to physical dependence and, some believe, make their effects temporary (see Effects, below). However, there is a significant amount of evidence that relapse rate of mental disorders negatively corresponds with length of properly followed treatment regimens (that is, relapse rate substantially declines over time), and to a much greater degree than placebo.
Many psychoactive substances are used for their mood and perception altering effects, including those with accepted uses in medicine and psychiatry. Examples include caffeine, alcohol, cocaine, LSD, and cannabis. Classes of drugs frequently used recreationally include:
- Stimulants, which activate the central nervous system. These are used recreationally for their euphoric effects.
- Hallucinogens (psychedelics, dissociatives and deliriants), which induce perceptual and cognitive distortions.
- Hypnotics, which depress the central nervous system.
- Opioid analgesics, which also depress the central nervous system. These are used recreationally because of their euphoric effects.
- Inhalants, in the forms of gas aerosols, or solvents, which are inhaled as a vapor because of their stupefying effects. Many inhalants also fall into the above categories (such as nitrous oxide which is also an analgesic).
In some modern and ancient cultures, drug usage is seen as a status symbol. Recreational drugs are seen as status symbols in settings such as at nightclubs and parties. For example, in ancient Egypt, gods were commonly pictured holding hallucinogenic plants.
Because there is controversy about regulation of recreational drugs, there is an ongoing debate about drug prohibition. Critics of prohibition believe that regulation of recreational drug use is a violation of personal autonomy and freedom. In the United States, critics have noted that prohibition or regulation of recreational and spiritual drug use might be unconstitutional, and causing more harm than is prevented.
Ritual and spiritual use
Certain psychoactives, particularly hallucinogens, have been used for religious purposes since prehistoric times. Native Americans have used peyote cacti containing mescaline for religious ceremonies for as long as 5700 years. The muscimol-containing Amanita muscaria mushroom was used for ritual purposes throughout prehistoric Europe. Various other hallucinogens, including jimsonweed, psilocybin mushrooms, and cannabis, have been used in religious ceremonies for millennia.
The use of entheogens for religious purposes resurfaced in the West during the counterculture movements of the 1960s and 70s. Under the leadership of Timothy Leary, new religious movements began to use LSD and other hallucinogens as sacraments. In the United States, the use of peyote for ritual purposes is protected only for members of the Native American Church, which is allowed to cultivate and distribute peyote. However, the genuine religious use of Peyote, regardless of one's personal ancestry, is protected in Colorado, Arizona, New Mexico, Nevada, and Oregon.
Psychoactive drugs have been used in military applications as non-lethal weapons. In World War II, between 1939 and 1945, 60 million amphetamine pills were made for use by soldiers. Brown-brown, a form of cocaine adulterated with gunpowder, has been used in the Sierra Leone Civil War by child soldiers.
Both military and civilian American intelligence officials are known to have used psychoactive drugs while interrogating captives apprehended in its War on Terror. In July 2012, Jason Leopold and Jeffrey Kaye, psychologists and human rights workers, had a Freedom of Information Act request fulfilled that confirmed that the use of psychoactive drugs during interrogation was a long-standing practice. Captives and former captives had been reporting medical staff collaborating with interrogators to drug captives with powerful psychoactive drugs prior to interrogation since the very first captives' release. In May 2003, recently released Pakistani captive Sha Mohammed Alikhel described the routine use of psychoactive drugs. He said that Jihan Wali, a captive kept in a nearby cell, was rendered catatonic through the use of these drugs.
For a substance to be psychoactive, it must cross the blood–brain barrier so it can affect neurochemical function. Psychoactive drugs are administered in several different ways. In medicine, most psychiatric drugs, such as fluoxetine, quetiapine, and lorazepam are ingested orally in tablet or capsule form. However, certain medical psychoactives are administered via inhalation, injection, or rectal suppository/enema. Recreational drugs can be administered in several additional ways that are not common in medicine. Certain drugs, such as alcohol and caffeine, are ingested in beverage form; nicotine and cannabis are often smoked; peyote and psilocybin mushrooms are ingested in botanical form or dried; and certain crystalline drugs such as cocaine and methamphetamines are often insufflated (inhaled or "snorted"). The efficiency of each method of administration varies from drug to drug.
Psychoactive drugs operate by temporarily affecting a person's neurochemistry, which in turn causes changes in a person's mood, cognition, perception and behavior. There are many ways in which psychoactive drugs can affect the brain. Each drug has a specific action on one or more neurotransmitter or neuroreceptor in the brain.
Drugs that increase activity in particular neurotransmitter systems are called agonists. They act by increasing the synthesis of one or more neurotransmitters, by reducing its reuptake from the synapses, or by mimicking the action by binding directly to the postsynaptic receptor. Drugs that reduce neurotransmitter activity are called antagonists, and operate by interfering with synthesis or blocking postsynaptic receptors so that neurotransmitters cannot bind to them.
Exposure to a psychoactive substance can cause changes in the structure and functioning of neurons, as the nervous system tries to re-establish the homeostasis disrupted by the presence of the drug (see also, Neuroplasticity). Exposure to antagonists for a particular neurotransmitter increases the number of receptors for that neurotransmitter, and the receptors themselves become more sensitive. This is called sensitization. Conversely, overstimulation of receptors for a particular neurotransmitter causes a decrease in both number and sensitivity of these receptors, a process called desensitization or tolerance. Sensitization and desensitization are more likely to occur with long-term exposure, although they may occur after only a single exposure. These processes are thought to underlie dependence and addiction. Physical dependence on antidepressants or anxiolytics may result in worse depression or anxiety, respectively, as withdrawal symptoms. Unfortunately, because clinical depression (also called major depressive disorder) is often referred to simply as depression, antidepressants are often requested by and prescribed for patients who are depressed, but not clinically depressed.
Affected neurotransmitter systems
The following is a brief table of notable drugs and their primary neurotransmitter, receptor or method of action. It should be noted that many drugs act on more than one transmitter or receptor in the brain.
Psychoactive drugs are often associated with addiction. Addiction can be divided into two types: psychological addiction, by which a user feels compelled to use a drug despite negative physical or societal consequence, and physical dependence, by which a user must use a drug to avoid physically uncomfortable or even medically harmful withdrawal symptoms. Not all drugs are physically addictive, but any activity that stimulates the brain's dopaminergic reward system — typically, any pleasurable activity — can lead to psychological addiction. Drugs that are most likely to cause addiction are drugs that directly stimulate the dopaminergic system, like cocaine and amphetamines. Drugs that only indirectly stimulate the dopaminergic system, such as psychedelics, are not as likely to be addictive.
Many professionals, self-help groups, and businesses specialize in drug rehabilitation, with varying degrees of success, and many parents attempt to influence the actions and choices of their children regarding psychoactives.
Common forms of rehabilitation include psychotherapy, support groups and pharmacotherapy, which uses psychoactive substances to reduce cravings and physiological withdrawal symptoms while a user is going through detox. Methadone, itself an opioid and a psychoactive substance, is a common treatment for heroin addiction, as is another opioid, buprenorphine. Recent research on addiction has shown some promise in using psychedelics such as ibogaine to treat and even cure addictions, although this has yet to become a widely accepted practice.
The legality of psychoactive drugs has been controversial through most of recent history; the Second Opium War and Prohibition are two historical examples of legal controversy surrounding psychoactive drugs. However, in recent years, the most influential document regarding the legality of psychoactive drugs is the Single Convention on Narcotic Drugs, an international treaty signed in 1961 as an Act of the United Nations. Signed by 73 nations including the United States, the USSR, India, and the United Kingdom, the Single Convention on Narcotic Drugs established Schedules for the legality of each drug and laid out an international agreement to fight addiction to recreational drugs by combatting the sale, trafficking, and use of scheduled drugs. All countries that signed the treaty passed laws to implement these rules within their borders. However, some countries that signed the Single Convention on Narcotic Drugs, such as the Netherlands, are more lenient with their enforcement of these laws.
In the United States, the Food and Drug Administration (FDA) has authority over all drugs, including psychoactive drugs. The FDA regulates which psychoactive drugs are over the counter and which are only available with a prescription. However, certain psychoactive drugs, like alcohol, tobacco, and drugs listed in the Single Convention on Narcotic Drugs are subject to criminal laws. The Controlled Substances Act of 1970 regulates the recreational drugs outlined in the Single Convention on Narcotic Drugs. Alcohol is regulated by state governments, but the federal National Minimum Drinking Age Act penalizes states for not following a national drinking age. Tobacco is also regulated by all fifty state governments. Most people accept such restrictions and prohibitions of certain drugs, especially the "hard" drugs, which are illegal in most countries.
In the medical context, psychoactive drugs as a treatment for illness is widespread and generally accepted. Little controversy exists concerning over the counter psychoactive medications in antiemetics and antitussives. Psychoactive drugs are commonly prescribed to patients with psychiatric disorders. However, certain critics believe that certain prescription psychoactives, such as antidepressants and stimulants, are overprescribed and threaten patients' judgement and autonomy.
- "CHAPTER 1 Alcohol and Other Drugs". ISBN 0-7245-3361-3.
- Nelson, Max (2005). The Barbarian's Beverage: A History of Beer in Ancient Europe. Abingdon, Oxon: Routledge. p. 1. ISBN 0-415-31121-7. Retrieved 21 September 2010.
- Merlin, M.D (2003). "Archaeological Evidence for the Tradition of Psychoactive Plant Use in the Old World". Economic Botany 57 (3): 295–323. doi:10.1663/0013-0001(2003)057[0295:AEFTTO]2.0.CO;2.
- Early Holocene coca chewing in northern Peru Volume: 84 Number: 326 Page: 939–953
- "Coca leaves first chewed 8,000 years ago, says research". BBC News. December 2, 2010.
- Siegel, Ronald K (2005). Intoxication: The Universal Drive for Mind-Altering Substances. Park Street Press, Rochester, Vermont. ISBN 1-59477-069-7.
- Weil, Andrew (2004). The Natural Mind: A Revolutionary Approach to the Drug Problem (Revised edition). Houghton Mifflin. p. 15. ISBN 0-618-46513-8.
- The Hashish Eater (1857) pg. 181
- Samorini, Giorgio (2002). Animals And Psychedelics: The Natural World & The Instinct To Alter Consciousness. Park Street Press. ISBN 0-89281-986-3.
- Albert, David Bruce, Jr. (1993). "Event Horizons of the Psyche". Retrieved February 2, 2006.
- http://www.leap.cc/cms/index.php?name=Content&pid=5. Retrieved 2013-05-30. Missing or empty
- "5 Years After: Portugal's Drug Decriminalization Policy Shows Positive Results". Scientific American. Retrieved 2013-05-30.
- Lovett, Richard (24 September 2005). "Coffee: The demon drink?" (fee required). New Scientist (2518). Retrieved 2007-11-19.
- Bersani FS, Corazza O, Simonato P, Mylokosta A, Levari E, Lovaste R, Schifano F (2013). "Drops of madness? Recreational misuse of tropicamide collyrium; early warning alerts from Russia and Italy". General Hospital Psychiatry 35 (5): 571–3. doi:10.1016/j.genhosppsych.2013.04.013. PMID 23706777.
- The Psychedelic Experience. New York: University Books. 1964
- Ratsch, Christian (May 5, 2005). The Encyclopedia of Psychoactive Plants. Park Street Press. p. 944. ISBN 0-89281-978-2.
- Medline Plus. Anesthesia. Accessed on July 16, 2007.
- Li X, Pearce RA (2000). "Effects of halothane on GABA(A) receptor kinetics: evidence for slowed agonist unbinding". The Journal of Neuroscience : The Official Journal of the Society for Neuroscience 20 (3): 899–907. PMID 10648694.
- Harrison NL, Simmonds MA (1985). "Quantitative studies on some antagonists of N-methyl D-aspartate in slices of rat cerebral cortex". British Journal of Pharmacology 84 (2): 381–91. doi:10.1111/j.1476-5381.1985.tb12922.x. PMC 1987274. PMID 2858237.
- Quiding H, Lundqvist G, Boréus LO, Bondesson U, Ohrvik J (1993). "Analgesic effect and plasma concentrations of codeine and morphine after two dose levels of codeine following oral surgery". European Journal of Clinical Pharmacology 44 (4): 319–23. doi:10.1007/BF00316466. PMID 8513842.
- Schatzberg AF (2000). "New indications for antidepressants". The Journal of Clinical Psychiatry 61 (11): 9–17. PMID 10926050.
- Hirschfeld, Robert (2001). "Clinical importance of long-term antidepressant treatment". The British Journal of Psychiatry 179 (s42): s4–s8. doi:10.1192/bjp.179.42.s4.
- Neuroscience of Psychoactive Substance Use and Dependence by the World Health Organization. Retrieved 5 July 2007.
- Anderson TL (1998). "Drug identity change processes, race, and gender. III. Macrolevel opportunity concepts". Substance Use & Misuse 33 (14): 2721–35. doi:10.3109/10826089809059347. PMID 9869440.
- Bertol E, Fineschi V, Karch SB, Mari F, Riezzo I (2004). "Nymphaea cults in ancient Egypt and the New World: a lesson in empirical pharmacology". Journal of the Royal Society of Medicine 97 (2): 84–5. doi:10.1258/jrsm.97.2.84. PMC 1079300. PMID 14749409.
- Hayry M (2004). "Prescribing cannabis: freedom, autonomy, and values". Journal of Medical Ethics 30 (4): 333–6. doi:10.1136/jme.2002.001347. PMC 1733898. PMID 15289511.
- Barnett, Randy E. "The Presumption of Liberty and the Public Interest: Medical Marijuana and Fundamental Rights". Retrieved 4 July 2007.
- El-Seedi HR, De Smet PA, Beck O, Possnert G, Bruhn JG (2005). "Prehistoric peyote use: alkaloid analysis and radiocarbon dating of archaeological specimens of Lophophora from Texas". Journal of Ethnopharmacology 101 (1-3): 238–42. doi:10.1016/j.jep.2005.04.022. PMID 15990261.
- Vetulani J (2001). "Drug addiction. Part I. Psychoactive substances in the past and presence". Polish Journal of Pharmacology 53 (3): 201–14. PMID 11785921.
- Hall, Andy. Entheogens and the Origins of Religion. Retrieved on May 13, 2007.
- Becker HS (1967). "History, culture and subjective experience: an exploration of the social bases of drug-induced experiences". Journal of Health and Social Behavior (American Sociological Association) 8 (3): 163–76. doi:10.2307/2948371. JSTOR 2948371. PMID 6073200.
- Bullis RK (1990). "Swallowing the scroll: legal implications of the recent Supreme Court peyote cases". Journal of Psychoactive Drugs 22 (3): 325–32. doi:10.1080/02791072.1990.10472556. PMID 2286866.
- Jason Leopold, Jeffrey Kaye (2011-07-11). "EXCLUSIVE: DoD Report Reveals Some Detainees Interrogated While Drugged, Others "Chemically Restrained"". Truthout. Archived from the original on 2012-07-14. "Truthout obtained a copy of the report - "Investigation of Allegations of the Use of Mind-Altering Drugs to Facilitate Interrogations of Detainees" - prepared by the DoD's deputy inspector general for intelligence in September 2009, under a Freedom of Information Act (FOIA) request we filed nearly two years ago."
- Robert Beckhusen (2012-07-11). "U.S. Injected Gitmo Detainees With ‘Mind Altering’ Drugs". Wired magazine. Archived from the original on 2012-07-14. Retrieved 2012-07-14. "That’s according to a recently declassified report (.pdf) from the Pentagon’s inspector general, obtained by Truthout‘s Jeffrey Kaye and Jason Leopold after a Freedom of Information Act Request. In it, the inspector general concludes that “certain detainees, diagnosed as having serious mental health conditions being treated with psychoactive medications on a continuing basis, were interrogated.” The report does not conclude, though, that anti-psychotic drugs were used specifically for interrogation purposes."
- Haroon Rashid (2003-05-23). "Pakistani relives Guantanamo ordeal". BBC News. Archived from the original on 2012-07-14. Retrieved 2009-01-09. "Mr Shah alleged that the Americans had given him injections and tablets prior to interrogations. "They used to tell me I was mad," the 23-year-old told the BBC in his native village in Dir district near the Afghan border. I was given injections at least four or five times as well as different tablets. I don't know what they were meant for.""
- Meek, James (2003-12-03). "People the law forgot". London: The Guardian. Archived from the original on 2012-07-14. Retrieved 2012-07-14. "The biggest damage is to my brain. My physical and mental state isn't right. I'm a changed person. I don't laugh or enjoy myself much."
- United States Food and Drug Administration. CDER Data Standards Manual. Retrieved on May 15, 2007.
- Seligma, Martin E.P. (1984). "4". Abnormal Psychology. W. W. Norton & Company. ISBN 0-393-94459-X.
- "University of Texas, Addiction Science Research and Education Center". Retrieved May 14, 2007.
- Lüscher C, Ungless MA (2006). "The mechanistic classification of addictive drugs". PLoS Medicine 3 (11): e437. doi:10.1371/journal.pmed.0030437. PMC 1635740. PMID 17105338.
- Ford, Marsha. Clinical Toxicology. Philadelphia: Saunders, 2001. Chapter 36 - Caffeine and Related Nonprescription Sympathomimetics. ISBN 0-7216-5485-1
- "Inhibitors of the Enzymic Hydrolysis of Endocannabinoids". Tocris.com. Retrieved 2013-11-23.
- Glick SD, Maisonneuve IS (May 1998). "Mechanisms of antiaddictive actions of ibogaine". Annals of the New York Academy of Sciences 844: 214–26. doi:10.1111/j.1749-6632.1998.tb08237.x.PMID 9668680.
- Nutt, D.; King, L. A.; Saulsbury, W.; Blakemore, C. (2007). "Development of a rational scale to assess the harm of drugs of potential misuse". The Lancet 369 (9566): 1047–1053. doi:10.1016/S0140-6736(07)60464-4. PMID 17382831.
- Johnson, Brian. (2002) Psychological Addiction, Physical Addiction, Addictive Character, and Addictive Personality Disorder: A Nosology of Addictive Disorders. Retrieved on July 5, 2007.
- Zhang J, Xu M (2001). "Toward a molecular understanding of psychostimulant actions using genetically engineered dopamine receptor knockout mice as model systems". Journal of Addictive Diseases 20 (3): 7–18. doi:10.1300/J069v20n04_02. PMID 11681595.
- Hops H, Tildesley E, Lichtenstein E, Ary D, Sherman L (1990). "Parent-adolescent problem-solving interactions and drug use". The American Journal of Drug and Alcohol Abuse 16 (3-4): 239–58. doi:10.3109/00952999009001586. PMID 2288323.
- "Psychedelics Could Treat Addiction Says Vancouver Official". Retrieved March 26, 2007.
- "Ibogaine research to treat alcohol and drug addiction". Retrieved March 26, 2007.
- United Nations Single Convention on Narcotic Drugs. Retrieved on June 20, 2007.
- MacCoun R, Reuter P (1997). "Interpreting Dutch cannabis policy: reasoning by analogy in the legalization debate". Science 278 (5335): 47–52. doi:10.1126/science.278.5335.47. PMID 9311925.
- History of the Food and Drug Administration. Retrieved at FDA's website on June 23, 2007.
- United States Controlled Substances Act of 1970. Retrieved from the DEA's website on June 20, 2007.
- Title 23 of the United States Code, Highways. Retrieved on June 20, 2007.
- Taxadmin.org. State Excise Tax Rates on Cigarettes. Retrieved on June 20, 2007.
- "What's your poison?". Caffeine. Retrieved July 12, 2006.
- Griffiths, RR (1995). Psychopharmacology: The Fourth Generation of Progress (4th edition). Lippincott Williams & Wilkins. p. 2002. ISBN 0-7817-0166-X.
- Edwards, Griffith (2005). Matters of Substance: Drugs--and Why Everyone's a User. Thomas Dunne Books. p. 352. ISBN 0-312-33883-X.
- Dworkin, Ronald. Artificial Happiness. New York: Carroll & Graf, 2006. pp.2-6. ISBN 0-7867-1933-8
- Manninen BA (2006). "Medicating the mind: a Kantian analysis of overprescribing psychoactive drugs". Journal of Medical Ethics 32 (2): 100–5. doi:10.1136/jme.2005.013540. PMC 2563334. PMID 16446415.