Ptolemy, one of the six somatophylakes (bodyguards) who served as Alexander the Great's generals and deputies, was appointed satrap of Egypt after Alexander's death in 323 BC. In 305 BC, he declared himself King Ptolemy I, later known as "Soter" (saviour). The Egyptians soon accepted the Ptolemies as the successors to the pharaohs of independent Egypt. Ptolemy's family ruled Egypt until the Roman conquest of 30 BC.
All the male rulers of the dynasty took the name Ptolemy. Ptolemaic queens, some of whom were the sisters of their husbands, were usually called Cleopatra, Arsinoe or Berenice. The most famous member of the line was the last queen, Cleopatra VII, known for her role in the Roman political battles between Julius Caesar and Pompey, and later between Octavian and Mark Antony. Her apparent suicide at the conquest by Rome marked the end of Ptolemaic rule in Egypt.
Dates in brackets represent the regnal dates of the Ptolemaic pharaohs. They frequently ruled jointly with their wives, who were often also their sisters. Several queens exercised regal authority, but the most famous and successful was Cleopatra VII (51–30 BC), with her two brothers and her son as successive nominal co-rulers. Several systems exist for numbering the later rulers; the one used here is the one most widely used by modern scholars. Dates are years of reign.
Contemporaries describe a number of the Ptolemaic dynasty as extremely obese, whilst sculptures and coins reveal prominent eyes and swollen necks. Familial Graves' disease could explain the swollen necks and eye prominence (exophthalmos), although this is unlikely to occur in the presence of morbid obesity.
In view of the familial nature of these findings, members of this dynasty likely suffered from a multi-organ fibrotic condition such as Erdheim–Chester disease or a familial multifocal fibrosclerosis where thyroiditis, obesity and ocular proptosis may have all occurred concurrently.
^Jones, Prudence J. (2006). Cleopatra: A Sourcebook. University of Oklahoma Press. p. 14. They were members of the Ptolemaic dynasty of Macedonian Greeks, who ruled Egypt after the death of its conqueror, Alexander the Great.
^Pomeroy, Sarah B. (1990). Women in Hellenistic Egypt. Wayne State University Press. p. 16. while Ptolemaic Egypt was a monarchy with a Greek ruling class.
^Redford, Donald B., ed. (2000). The Oxford Encyclopedia of Ancient Egypt. Oxford University Press. Cleopatra VII was born to Ptolemy XII Auletes (80–57 BCE, ruled 55–51 BCE) and Cleopatra, both parents being Macedonian Greeks.
^Bard, Kathryn A., ed. (1999). Encyclopedia of the Archaeology of Ancient Egypt. Routledge. p. 488. Ptolemaic kings were still crowned at Memphis and the city was popularly regarded as the Egyptian rival to Alexandria, founded by the Macedonian Greeks.
^Bard, Kathryn A., ed. (1999). Encyclopedia of the Archaeology of Ancient Egypt. Routledge. p. 687. During the Ptolemaic period, when Egypt was governed by rulers of Greek descent...
^Ashrafian, Hutan (2005). "Familial proptosis and obesity in the Ptolemies". J. R. Soc. Med.98 (2): 85–86.