Pulmonary surfactant-associated protein B

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Surfactant protein B
PDB 1dfw EBI.jpg
Rendering of 1DFW
Available structures
PDB Ortholog search: PDBe, RCSB
External IDs OMIM178640 MGI109516 HomoloGene456 GeneCards: SFTPB Gene
RNA expression pattern
PBB GE SFTPB 213936 x at tn.png
PBB GE SFTPB 214354 x at tn.png
More reference expression data
Species Human Mouse
Entrez 6439 20388
Ensembl ENSG00000168878 ENSMUSG00000056370
UniProt P07988 P50405
RefSeq (mRNA) NM_000542 NM_001282071
RefSeq (protein) NP_000533 NP_001269000
Location (UCSC) Chr 2:
85.88 – 85.9 Mb
Chr 6:
72.3 – 72.31 Mb
PubMed search [1] [2]

Pulmonary surfactant-associated protein B is a protein that in humans is encoded by the SFTPB gene.[1][2][3]

Pulmonary surfactant-associated protein B' is a membrane protein which manufactures surfactant.

Clinical significance[edit]

Humans and animals born with a congenital absence of SP-B suffer from intractable respiratory failure.

It is associated with Surfactant metabolism dysfunction type 1.

See also[edit]


  1. ^ Pilot-Matias TJ, Kister SE, Fox JL, Kropp K, Glasser SW, Whitsett JA (May 1989). "Structure and organization of the gene encoding human pulmonary surfactant proteolipid SP-B". DNA 8 (2): 75–86. doi:10.1089/dna.1.1989.8.75. PMID 2924687. 
  2. ^ Moore KJ, D'Amore-Bruno MA, Korfhagen TR, Glasser SW, Whitsett JA, Jenkins NA, Copeland NG (Mar 1992). "Chromosomal localization of three pulmonary surfactant protein genes in the mouse". Genomics 12 (2): 388–93. doi:10.1016/0888-7543(92)90389-A. PMID 1346779. 
  3. ^ "Entrez Gene: SFTPB surfactant, pulmonary-associated protein B". 

Further reading[edit]

External links[edit]