With the opening of the interchange, Service 83, plying between Sengkang and Punggol, was amended to terminate here, instead of the pair of bus-stops below Punggol. Also, Punggol Road End Bus Terminal closed. The terminal's only bus route, Service 82, was amended to loop at the former terminal. Service 3 was extended from its original looping point at Pasir Ris Street 71 to provide direct links between Punggol and the new towns of Pasir Ris and Tampines, while Service 62 and Service 136 were extended from the former Hougang South Bus Interchange and Upper Serangoon Road to this interchange respectively.
On 21 October 2012, under the Bus Service Enhancement Programme (BSEP), Service 119 was extended to terminate at Punggol Bus Interchange instead of terminating at Sengkang Bus Interchange, calling at an additional four pairs of bus stops.
On 16 December 2012, under the Bus Service Enhancement Programme (BSEP), Service 50 was introduced. The service plies between Punggol and Bishan Bus Interchange.