Punk in Drublic is NOFX's most successful album to date, peaking at number 12 on Billboard's Heatseekers chart. The album has received positive reviews and is now considered a classic punk album by fans and critics alike. Six years after its release, it became the band's only gold record for sales of over 500,000 copies in the United States, all without any radio play or aired music videos (although a video was made for the song "Leave It Alone"). Worldwide, the record has sold over 1 million copies.
The Allmusic review by Stephen Thomas Erlewine awards the album 4.5 stars and states: "The quartet didn't change their approach at all — at their core, they remain a heavy, speed-addled, hook-conscious post-hardcore punk group — but their songwriting has improved, as has their attack."