Inside of the stomach (pylorus labeled at center left)
The pylorus (// or //), or pyloric part, is the region of the stomach that connects to the duodenum (not to be confused with the pyloric glands, which are analogous to the gastric glands (although currently referred to as the fundic glands)). The pylorus is considered as having two parts, the pyloric antrum (opening to the body of the stomach) and the pyloric canal (opening to the duodenum). The pyloric canal ends as the pyloric orifice, which marks the junction between the stomach and the duodenum. The orifice is surrounded by a sphincter, a band of muscle, called the pyloric sphincter.
The word pylorus comes from the Greek πυλωρός, "gate guard".
The pylorus is the part of the stomach that connects to the duodenum. It is divided into two parts, the antrum, which connects to the body of the stomach, and the pyloric canal, which connects to the duodenum.
The pyloric antrum is the initial portion of the pylorus. It is near the bottom of the stomach, proximal to the pyloric sphincter, which separates the stomach and the duodenum. It may temporarily become partially or completely shut off from the remainder of the stomach during digestion by peristaltic contraction of the prepyloric sphincter; it is demarcated, sometimes, from the pyloric canal by a slight groove.
The pyloric sphincter, or valve, is a strong ring of smooth muscle at the end of the pyloric canal which lets food pass from the stomach to the duodenum. It receives sympathetic innervation from the celiac ganglion.
Under microscopy, the pylorus contains numerous glands, including gastric pits, which constitute about half the depth of the pyloric mucosa. They consist of two or three short closed tubes opening into a common duct or mouth. These tubes are wavy, and are about one-half the length of the duct. The duct is lined by columnar cells, continuous with the epithelium lining the surface of the mucous membrane of the stomach, the tubes by shorter and more cubical cell which are finely granular. The glands contain mucus cells and G cells that secrete gastrin.
The pylorus also contains scattered parietal cells and neuroendocrine cells. These endocrine cells including G cells, which produce gastrin, which stimulates gastric acid production, and D cells, which release somatostatin. (responsible for shutting off acid secretion. There is a second hormone-sensitive population near the fundus.)
The pylorus is one component of the gastrointestinal system. Food from the stomach passes through the pylorus to the duodenum. The pylorus, through the pyloric sphincter, regulates entry of food from the stomach into the duodenum.
In such conditions as stomach cancer, tumours may partly block the pyloric canal. A special tube can be implanted surgically to connect the stomach to the duodenum so as to facilitate the passage of food from one to the other. This tube is called a gastroduodenostomy.
Pyloric stenosis refers to a pylorus that is narrow. This is due to congenital hypertrophy of the pyloric sphincter. The lumen of the pylorus is narrower, and less food is able to pass through. This problem is often detected in the early weeks of life. When it is present, a newborn baby may projectile vomit after eating, but despite vomiting remain hungry. Pyloric stenosis may be managed by the insertion of a stent, or through surgical cutting of the pyloric sphincter, a pyloromyotomy. 
- This article uses anatomical terminology; for an overview, see anatomical terminology.
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- University of Illinois Medical Center:Health Library
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- Anatomy photo:37:06-0105 at the SUNY Downstate Medical Center - "Abdominal Cavity: The Stomach"
- Anatomy photo:38:07-0102 at the SUNY Downstate Medical Center - "Stomach, Spleen and Liver: The Pylorus"
- Anatomy image:8150 at the SUNY Downstate Medical Center